A Computational Study on Renal Artery Anatomy in Patients Treated with Fenestrated or Branched Endovascular Aneurysm Repair.

IF 3.8 3区 医学 Q2 ENGINEERING, BIOMEDICAL
Yuzhu Wang, Yuna Sang, Wendong Li, Minjie Zhou, Yushun Zhao, Xiaodong He, Chao Wang, Xiaoqiang Li, Zhao Liu
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引用次数: 0

Abstract

(1) Background: Renal artery occlusion after F/B EVAR for abdominal aortic aneurysm is a serious complication that may require re-intervention, and understanding the hemodynamic mechanisms by which it occurs is essential to optimize the surgical procedure. (2) Methods: We used computational fluid dynamics (CFD) to analyze the impact of various parameters on blood flow. Theoretical vascular models were constructed based on the common dimensions and angles of aortic stents and branch arteries in clinical practice. Actual case models were constructed from CT image data of six patients treated with F/B-EVAR. Data were collected for analysis after simulation and calculation by FLUENT software. (3) Results: Theoretical model simulations showed that a larger tilt angle of the branch stent, smaller branch entry depth, and larger branch stent diameter were beneficial for blood flow. In the case models, a significant difference in the tilt angle of the renal artery stents was observed between the high- and low-flow groups, while the differences in entry depth and branch stent diameter were not significant. Occluded renal arteries had lower WSS values than patent ones. (4) Conclusions: This study offers valuable guidance for optimizing stent placement in F/B EVAR to mitigate renal artery occlusion risk.

开窗或分支血管内动脉瘤修复患者肾动脉解剖的计算研究。
(1)背景:腹主动脉瘤F/B EVAR后肾动脉闭塞是一种严重的并发症,可能需要再次干预,了解其发生的血流动力学机制对优化手术程序至关重要。(2)方法:采用计算流体力学(CFD)分析各参数对血流的影响。根据临床常用的主动脉支架和支动脉的尺寸和角度,建立理论血管模型。根据6例F/B-EVAR患者的CT图像资料构建实际病例模型。通过FLUENT软件进行仿真计算,收集数据进行分析。(3)结果:理论模型模拟表明,支路支架倾斜角度越大、支路进入深度越小、支路支架直径越大有利于血流。在病例模型中,高流量组和低流量组肾动脉支架的倾斜角有显著差异,而入路深度和支路支架直径差异不显著。闭塞的肾动脉比通畅的肾动脉WSS值低。(4)结论:本研究为F/B EVAR优化支架置入,降低肾动脉闭塞风险提供有价值的指导。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Bioengineering
Bioengineering Chemical Engineering-Bioengineering
CiteScore
4.00
自引率
8.70%
发文量
661
期刊介绍: Aims Bioengineering (ISSN 2306-5354) provides an advanced forum for the science and technology of bioengineering. It publishes original research papers, comprehensive reviews, communications and case reports. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. All aspects of bioengineering are welcomed from theoretical concepts to education and applications. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. There are, in addition, four key features of this Journal: ● We are introducing a new concept in scientific and technical publications “The Translational Case Report in Bioengineering”. It is a descriptive explanatory analysis of a transformative or translational event. Understanding that the goal of bioengineering scholarship is to advance towards a transformative or clinical solution to an identified transformative/clinical need, the translational case report is used to explore causation in order to find underlying principles that may guide other similar transformative/translational undertakings. ● Manuscripts regarding research proposals and research ideas will be particularly welcomed. ● Electronic files and software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material. ● We also accept manuscripts communicating to a broader audience with regard to research projects financed with public funds. Scope ● Bionics and biological cybernetics: implantology; bio–abio interfaces ● Bioelectronics: wearable electronics; implantable electronics; “more than Moore” electronics; bioelectronics devices ● Bioprocess and biosystems engineering and applications: bioprocess design; biocatalysis; bioseparation and bioreactors; bioinformatics; bioenergy; etc. ● Biomolecular, cellular and tissue engineering and applications: tissue engineering; chromosome engineering; embryo engineering; cellular, molecular and synthetic biology; metabolic engineering; bio-nanotechnology; micro/nano technologies; genetic engineering; transgenic technology ● Biomedical engineering and applications: biomechatronics; biomedical electronics; biomechanics; biomaterials; biomimetics; biomedical diagnostics; biomedical therapy; biomedical devices; sensors and circuits; biomedical imaging and medical information systems; implants and regenerative medicine; neurotechnology; clinical engineering; rehabilitation engineering ● Biochemical engineering and applications: metabolic pathway engineering; modeling and simulation ● Translational bioengineering
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