Cross-sectional analysis of factors associated with low intrinsic capacity among Malaysians ageing with HIV in ambulatory care.

IF 3.1 2区医学 Q3 IMMUNOLOGY

AIDS Pub Date : 2025-09-01 Epub Date: 2025-05-23 DOI:10.1097/QAD.0000000000004246

Siew Hwei Yap, Syaza Hisham, Wen Ying Ho, William Boon Wei Hor, Xin Woen Tan, Nurul Syuhada Zulhaimi, Jessica Seh Min Loh, Malinee Neelamegam, Kejal Hasmukharay, Han Cheng Ong, Reuben Robbins, Pui Li Wong, Reena Rajasuriar

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引用次数: 0

Abstract

Objective: Intrinsic capacity is a component of WHO's model for Health Ageing and a key determinant of an individual's functional ability as they age. However, little is known about what factors negatively influence intrinsic capacity among people with HIV (PWH).

Design: Cross-sectional study.

Method: Participants included PWH [≥35 years and on antiretroviral therapy (ART) for a minimum of 12 months] attending HIV care in University Malaya Medical Centre. Intrinsic capacity scores were computed based on five key domains (sensory, mobility, cognition, vitality, and mood). Pareto analyses were performed to determine the domains impaired in the majority of participants, and multivariable linear regression to explore factors associated with low intrinsic capacity.

Results: The median age in the 202 PWH were 50 years [interquartile range (IQR): 44-57 years] and median intrinsic capacity score was 5.60 (IQR: 4.80-5.80, max 6). Deficits in vitality were observed in 52.8% of participants, followed by cognition (18.8%) and mood (18.1%). Factors associated with low intrinsic capacity scores after adjusting for demographic and socioeconomic factors included multimorbidity [-0.130, 95% confidence interval (CI): -0.181, -0.079, P = 0.000] and polypharmacy (-0.077, 95% CI: -0.119, -0.036, P = 0.000), metabolic syndrome (-0.360, 95% CI: -0.568, -0.153, P = 0.001), renal disease (-0.450, 95% CI: -0.871, -0.029, P = 0.036) and diabetes (-0.337, 95% CI: -0.590, -0.085, P = 0.009), social isolation (0.021, 95% CI: 0.003, 0.039, P = 0.025), loneliness (-0.063, 95% CI: -0.114, -0.013, P = 0.014) and high high-sensitive C-reactive protein (hsCRP) (-0.028, 95% CI: -0.054, -0.002, P = 0.034).

Conclusion: Poor social connectedness and multimorbidity, particularly metabolic syndrome and renal disease, are significant risk factors for low intrinsic capacity scores among PWH in our setting. This study provides critical insights into potential strategies to improve trajectories of healthy ageing in PWH.

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与低内在能力相关的因素横断面分析在马来西亚老年人与艾滋病毒在门诊护理。

目的：内在能力（IC）是世卫组织健康老龄化模型的一个组成部分，也是个人随年龄增长的功能能力的关键决定因素。然而，对于哪些因素会对HIV感染者（PWH）的IC产生负面影响，我们知之甚少。设计：横断面研究。方法：参与者包括在马来亚大学医学中心接受HIV治疗的PWH（≥35岁，接受ART治疗至少12个月）。IC分数是根据五个关键领域（感觉、活动、认知、活力和情绪）计算的。结果：202名PWH患者的中位年龄为50岁（IQR:44 ~ 57岁），中位IC评分为5.60 （IQR:4.80 ~ 5.80, max 6）。52.8%的参与者存在活力缺陷，其次是认知（18.8%）和情绪（18.1%）。IC分值较低的相关因素调整后的人口和社会经济因素包括multimorbidity(-0.130, 95%置信区间ci: -0.181, -0.079, p = 0.000)和复方用药(-0.077,95%置信区间ci: -0.119, -0.036, p = 0.000),代谢综合征(-0.360,95%置信区间ci: -0.568, -0.153, p = 0.001),肾脏疾病(-0.450,95%置信区间ci: -0.871, -0.029, p = 0.036),和糖尿病(-0.337,95%置信区间ci: -0.590, -0.085, p = 0.009),社会孤立(0.021,95%置信区间ci: 0.003, 0.039, p = 0.025),孤独(-0.063,95%置信区间ci:-0.114, -0.013, p = 0.014)和高hsCRP(-0.028, 95%置信区间ci: -0.054, -0.002, p = 0.034)。结论：社会联系不良和多病，特别是代谢综合征和肾脏疾病，是我们环境中PWH中IC评分低的重要危险因素。本研究为改善PWH健康老龄化轨迹的潜在策略提供了重要见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

AIDS 医学-病毒学

CiteScore

5.90

自引率

5.30%

发文量

478

审稿时长

3 months

期刊介绍： Publishing the very latest ground breaking research on HIV and AIDS. Read by all the top clinicians and researchers, AIDS has the highest impact of all AIDS-related journals. With 18 issues per year, AIDS guarantees the authoritative presentation of significant advances. The Editors, themselves noted international experts who know the demands of your work, are committed to making AIDS the most distinguished and innovative journal in the field. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.