Thyroid cancer surgical indication during pregnancy: Systematic literature review and series of illustrative cases

IF 1.7 4区医学 Q2 OTORHINOLARYNGOLOGY

Brazilian Journal of Otorhinolaryngology Pub Date : 2025-05-28 DOI:10.1016/j.bjorl.2025.101643

Lucas Albuquerque Chinelatto, Flávio Carneiro Hojaij , Dorival de Carlucci Jr., Claudio Roberto Cernea

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引用次数: 0

Abstract

Objective

To evaluate and discuss timing possibilities for surgical treatment in thyroid cancer in pregnant women.

Methods

Systematic literature review based on online search at the Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) and National Center for Biotechnology Information (NCBI) databases. Retrospective analysis of thyroidectomies performed in the second trimester of pregnancy by the authors between 1999 and 2019.

Results

The systematic review included nine articles. Their conclusions diverge with respect to the optimal timing of thyroid surgery. The medical literature considers thyroidectomy after safe delivery. The most recent studies are more flexible regarding carrying out this surgery during the second trimester of pregnancy. In the authors’ experience (n = 5), surgical treatment during the second trimester of pregnancy is a good option for more aggressive tumors.

Conclusion

More aggressive cases of thyroid papillary carcinoma can be treated with surgery during the second trimester of pregnancy. Performing the surgery after delivery is safer in the case of less aggressive cancer cases. The decision should consider hospital costs, surgery risks, and patient anxiety in relation to cancer.

Level of evidence

Level II.

查看原文本刊更多论文

妊娠期甲状腺癌手术指征：系统的文献回顾和一系列说明性病例

目的探讨孕妇甲状腺癌手术治疗时机的可行性。方法基于联机检索拉丁美洲和加勒比文献Ciências da Saúde （LILACS）和美国国家生物技术信息中心（NCBI）数据库进行系统文献综述。回顾性分析1999年至2019年作者在妊娠中期进行的甲状腺切除术。结果系统评价纳入9篇文献。关于甲状腺手术的最佳时机，他们的结论存在分歧。医学文献认为安全分娩后应行甲状腺切除术。最近的研究对于在妊娠中期进行这种手术更为灵活。根据作者的经验（n = 5），对于更具侵袭性的肿瘤，在妊娠中期进行手术治疗是一个很好的选择。结论侵袭性甲状腺乳头状癌在妊娠中期可行手术治疗。在癌症侵袭性较弱的情况下，分娩后进行手术更安全。该决定应考虑到医院费用、手术风险以及与癌症相关的患者焦虑。证据等级：II级。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brazilian Journal of Otorhinolaryngology OTORHINOLARYNGOLOGY-

CiteScore

3.00

自引率

0.00%

发文量

205

审稿时长

4-8 weeks

期刊介绍： Brazilian Journal of Otorhinolaryngology publishes original contributions in otolaryngology and the associated areas (cranio-maxillo-facial surgery and phoniatrics). The aim of this journal is the national and international divulgation of the scientific production interesting to the otolaryngology, as well as the discussion, in editorials, of subjects of scientific, academic and professional relevance. The Brazilian Journal of Otorhinolaryngology is born from the Revista Brasileira de Otorrinolaringologia, of which it is the English version, created and indexed by MEDLINE in 2005. It is the official scientific publication of the Brazilian Association of Otolaryngology and Cervicofacial Surgery. Its abbreviated title is Braz J Otorhinolaryngol., which should be used in bibliographies, footnotes and bibliographical references and strips.