Metastatic basal cell carcinoma: Case series and literature review

IF 1.7 4区医学 Q2 OTORHINOLARYNGOLOGY

Brazilian Journal of Otorhinolaryngology Pub Date : 2025-05-28 DOI:10.1016/j.bjorl.2025.101619

Mariana Gonçalves Rodrigues , Aline Vieira de Lucena , Gabriela Alves Domingues , Caroline Marques de Aquino , Deborah Yukiko Otto , André Bandiera de Oliveira Santos , Luiz Paulo Kowalski

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引用次数: 0

Abstract

Objective

To present a metastatic head and neck basal cell carcinoma (BCC) series treated by a university teaching service between 1993 and 2021.

Methods

A review of medical records of 500 patients with high-risk BCC in the head and neck was performed. Tumors with a diameter greater than or equal to 6 mm in the “H” area of the face or greater than 10 mm in other head and neck areas; recurrences; sclerodermiform, micronodular and metatypical subtypes; and perineural invasion were considered factors indicating high-risk.

Results

Seven cases of metastatic head and neck BCC were diagnosed. The mean age at diagnosis of the primary tumor was 49.8 years, and the median time between the diagnosis of the primary tumor and that of metastases was 3 years (ranging from 1 to 20 years). The main site of metastasis was the lymph nodes. The main modalities of metastases treatment were surgery and radiotherapy.

Conclusion

BCC metastasis is a rare manifestation of a frequent disease. Post-treatment follow-up should include routine clinical examination of the neck for all patients and imaging for the diagnosis of metastases in symptomatic patients.

Level of evidence

Level IV.

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转移性基底细胞癌：病例系列及文献回顾

目的介绍1993年至2021年间某大学教学部门治疗的一例转移性头颈部基底细胞癌（BCC）。方法回顾性分析500例头颈部高危基底细胞癌患者的临床资料。面部“H”区直径大于或等于6mm或头颈部其他区域直径大于10mm的肿瘤；复发;硬皮型、微结节型和超非典型亚型；神经周围侵犯被认为是高危因素。结果本组共确诊头颈部转移性基底细胞癌7例。原发肿瘤诊断的平均年龄为49.8岁，从原发肿瘤诊断到转移的中位时间为3年（1 ~ 20岁）。转移部位以淋巴结为主。转移治疗的主要方式是手术和放疗。结论乳腺癌转移是一种罕见的常见病。治疗后随访应包括对所有患者进行颈部常规临床检查，对有症状的患者进行影像学检查以诊断转移。证据等级：四级。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brazilian Journal of Otorhinolaryngology OTORHINOLARYNGOLOGY-

CiteScore

3.00

自引率

0.00%

发文量

205

审稿时长

4-8 weeks

期刊介绍： Brazilian Journal of Otorhinolaryngology publishes original contributions in otolaryngology and the associated areas (cranio-maxillo-facial surgery and phoniatrics). The aim of this journal is the national and international divulgation of the scientific production interesting to the otolaryngology, as well as the discussion, in editorials, of subjects of scientific, academic and professional relevance. The Brazilian Journal of Otorhinolaryngology is born from the Revista Brasileira de Otorrinolaringologia, of which it is the English version, created and indexed by MEDLINE in 2005. It is the official scientific publication of the Brazilian Association of Otolaryngology and Cervicofacial Surgery. Its abbreviated title is Braz J Otorhinolaryngol., which should be used in bibliographies, footnotes and bibliographical references and strips.