Evaluation of dose delivery accuracy of the lung with the respiratory technique of the Radixact Synchrony real-time tumor tracking system

Q1 Nursing
Evren Ozan Göksel
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Abstract

Purpose

This study aims to evaluate the dosimetric accuracy of the Lung with Respiratory (LWR) technique in the Radixact Synchrony real-time tumor tracking system using data from actual patients undergoing lung SBRT.

Material and methods

This retrospective study included 20 patients treated with the Synchrony LWR technique for primary lung cancer or lung metastases. Mid-ventilation breath-hold CT and 4DCT images were acquired for treatment planning and tumor motion evaluation. Gamma analysis was performed using the PTW 1500 detector. Three verification plans were generated for each patient: one for gamma analysis without motion (GAWoM), one for point dose measurement with motion (PDWM), and one for gamma analysis with motion (GAWM). Patient specific respiratory motion was simulated using a CIRS motion platform. The relationship between respiratory patterns, treatment plan parameters, and the dose delivery accuracy of the Synchrony system was evaluated using correlation analysis.

Results

The PDWM results demonstrated a strong agreement between the planned and measured doses, with a maximum difference of less than 2%. The gamma passing rates of 3D dose measurements for all patients’ Synchrony plans were found to be within the clinically acceptable level. While GAWM results were slightly lower than GAWoM results, correlation analysis revealed a strong positive relationship between the two. A moderate negative correlation was observed between the modulation factor and GAWM, similar to GAWoM. Additionally, a strong negative correlation was observed between beam-on time and both GAWoM and GAWM. Furthermore, no significant correlation was found between GAWM and respiratory pattern-related variables, including superior-inferior and lateral motion amplitude or respiratory rate per minute.

Conclusion

The results of the correlation analyses indicate that the dose delivery accuracy of the Synchrony LWR technique is comparable to that of static target irradiation, independent of the patient’s respiratory pattern or the planning parameters used.
Radixact同步实时肿瘤跟踪系统呼吸技术对肺给药准确性的评价
目的本研究旨在评估Radixact同步实时肿瘤跟踪系统中肺伴呼吸(LWR)技术的剂量学准确性,数据来源于接受肺部SBRT的实际患者。材料和方法本回顾性研究包括20例采用同步LWR技术治疗原发性肺癌或肺转移的患者。获得中期通气屏气CT和4DCT图像,用于治疗计划和肿瘤运动评估。使用PTW 1500探测器进行伽马分析。为每位患者生成三个验证计划:一个是无运动伽马分析(GAWoM),一个是运动点剂量测量(PDWM),一个是运动伽马分析(GAWM)。使用CIRS运动平台模拟患者的特定呼吸运动。采用相关分析评价呼吸方式、治疗方案参数与同步系统给药准确性之间的关系。结果PDWM结果显示计划剂量和测量剂量之间有很强的一致性,最大差异小于2%。所有患者同步计划的3D剂量测量伽马通过率均在临床可接受水平内。虽然GAWM结果略低于GAWoM结果,但相关分析显示两者之间存在较强的正相关关系。调制因子与GAWM呈中等负相关,与GAWM相似。此外,波束时间与GAWoM和GAWM均呈显著负相关。此外,GAWM与呼吸模式相关变量(包括上下运动幅度和侧运动幅度或每分钟呼吸频率)之间没有显著相关性。结论相关分析结果表明,同步LWR技术的剂量传递精度与静态靶照射相当,与患者的呼吸方式或使用的计划参数无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.10
自引率
0.00%
发文量
48
审稿时长
67 days
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