Recent advances in dietary phytochemicals against Alzheimer’s disease: extraction and multitarget evaluation of their effects

IF 8.9 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Current Opinion in Food Science Pub Date : 2025-05-20 DOI:10.1016/j.cofs.2025.101312

Mikaela Rajchman , Lidia Montero , Alberto Valdés , Miguel Herrero

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引用次数: 0

Abstract

The rise in life expectancy is associated with the increased prevalence of age-related diseases, such as neurodegeneration or dementia. Alzheimer's disease (AD) is the most prevalent neurodegenerative disease worldwide, associated with a complex interaction among genetic, neurological, and environmental factors. Epidemiological studies have evidenced that lifestyle, including physical exercise, tobacco and alcohol consumption, as well as diet, interacts with the main routes of AD development. In recent years, the ability of some phytochemicals found in natural sources, such as plants, foods, and algae, has been studied for their potential as neuroprotective agents. In this review, the latest advances in the extraction of these natural bioactive compounds, involving the use of emergent green extraction techniques and novel green bio-based solvents, are presented. Moreover, different in vitro and in vivo assays and analytical tools used under a multitarget approach to elucidate the mechanisms of action of these compounds are summarized. Finally, future trends in the use of phytochemicals as potential neuroprotective agents are critically discussed.

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抗阿尔茨海默病膳食植物化学物质的研究进展：提取及其多靶点评价

预期寿命的增加与年龄相关疾病的患病率增加有关，如神经变性或痴呆症。阿尔茨海默病（AD）是世界上最常见的神经退行性疾病，与遗传、神经和环境因素的复杂相互作用有关。流行病学研究已经证明，生活方式，包括体育锻炼、烟酒消费以及饮食，与AD发展的主要途径相互作用。近年来，人们研究了一些天然来源的植物化学物质，如植物、食物和藻类，它们作为神经保护剂的潜力。本文综述了天然生物活性化合物提取的最新进展，包括新兴的绿色提取技术和新型绿色生物基溶剂的使用。此外，还总结了在多靶点方法下用于阐明这些化合物的作用机制的不同体外和体内试验和分析工具。最后，讨论了植物化学物质作为潜在神经保护剂的未来发展趋势。

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来源期刊

Current Opinion in Food Science Agricultural and Biological Sciences-Food Science

CiteScore

18.40

自引率

4.00%

发文量

157

审稿时长

92 days

期刊介绍： Current Opinion in Food Science specifically provides expert views on current advances in food science in a clear and readable format. It also evaluates the most noteworthy papers from original publications, annotated by experts. Key Features: Expert Views on Current Advances: Clear and readable insights from experts in the field regarding current advances in food science. Evaluation of Noteworthy Papers: Annotated evaluations of the most interesting papers from the extensive array of original publications. Themed Sections: The subject of food science is divided into themed sections, each reviewed once a year.