Photoredox catalysis enabled selective CN bond cleavage in ring-strained tertiary amines

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-05-23 DOI:10.1016/j.tetlet.2025.155666

Yu Zhou, Pu-Sheng Wang

引用次数: 0

Abstract

The selective cleavage of CN bonds in tertiary amines to form secondary amines is a promising strategy for constructing diverse nitrogen-containing compounds. Herein, we introduce a simple method for the selective N-dealkylation of ring-strained tertiary amines under blue LED light irradiation using 4CzIPN as photocatalyst and CCl₄ as oxidant with up to 99% yield.

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光氧化还原催化使环应变叔胺的CN键选择性裂解

叔胺中CN键的选择性裂解形成仲胺是构建多种含氮化合物的一种很有前途的策略。本文介绍了一种在蓝光LED光照射下，以4CzIPN为光催化剂，CCl4为氧化剂，进行环应变叔胺选择性n -脱烷基反应的简单方法，收率高达99%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.