Men and women differ with regard to the prevalence, phenotype, and prognosis of wild-type transthyretin amyloid cardiomyopathy.

IF 7.4 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Amyloid-Journal of Protein Folding Disorders Pub Date : 2025-09-01 Epub Date: 2025-05-27 DOI:10.1080/13506129.2025.2507921

Amira Zaroui, Charlotte Lafont, Mounira Kharoubi, Etienne Audureau, Mélanie Bézard, Mouna Hentati, Gagan Deep Singh Chadha, Emmanuel Teiger, Emmanuel Itti, Nicolas Lellouche, Soraya Fellahi, Amaury Broussier, Florence Canoui-Poitrine, Thibaud Damy

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引用次数: 0

Abstract

Background: We explored sex differences in wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM) and determined survival and prognostic factors.

Methods: In a retrospective cohort study at a reference centre in France from 1 January 2008 to 31 December 2022, multiple regression analyses, supervised clustering, Cox models, and a Kaplan-Meier analysis were used to compare women and men in each age quartile (Q1: ≤77 years; Q2: 78-82; Q3: 83-86; Q4 > 86).

Results: We included 1062 patients with ATTRwt-CM (180 women, 16%). The women had a higher median [IQR] left ventricular ejection fraction (LVEF; 52% [45-60] vs. 50 [43-58] in men) and a thinner interventricular septum. 12% of women and 4.1% of men had a septum thickness <12 mm (p = 0.004). The women in Q1 had lower LVEF and global longitudinal strain values and a higher prevalence of a septum <12 mm (15.8%, vs 2.0% in men) than men and older women (Q2-Q3-Q4). Women had a greater risk of sudden death than men (13.8% vs. 4.6%, respectively; odds ratio [95% confidence interval]: 3.24 [1.56-6.64]; p = 0.001).

Conclusions: In women, the ATTRwt-CM phenotype and prognosis are related to age at diagnosis. Decreasing the septum thickness cut-off would increase the frequency of ATTR-CM diagnosis in women.

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男性和女性在野生型转甲状腺蛋白淀粉样心肌病的患病率、表型和预后方面存在差异。

背景：我们探讨野生型转甲状腺素淀粉样心肌病（ATTRwt-CM）的性别差异，并确定生存和预后因素。方法：2008年1月1日至2022年12月31日，在法国某参考中心进行回顾性队列研究，采用多元回归分析、监督聚类、Cox模型和Kaplan-Meier分析比较每个年龄四分位数(Q1:≤77岁；Q2: 78 - 82;第三季度:83 - 86;q4 bb0 86)。结果：我们纳入1062例attrt - cm患者（180例女性，16%）。这些女性的左心室射血分数（LVEF）中位数较高；52%[45-60]，男性为50%[43-58])，室间隔较薄。12%的女性和4.1%的男性有隔膜厚度（p = 0.004）。第一季度的女性LVEF和整体纵向应变值较低，中隔患病率较高（p = 0.001）。结论：在女性中，attrt - cm表型和预后与诊断年龄有关。降低鼻中隔厚度临界值会增加女性atr - cm的诊断频率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Amyloid-Journal of Protein Folding Disorders 生物-生化与分子生物学

CiteScore

10.60

自引率

10.90%

发文量

审稿时长

6-12 weeks

期刊介绍： Amyloid: the Journal of Protein Folding Disorders is dedicated to the study of all aspects of the protein groups and associated disorders that are classified as the amyloidoses as well as other disorders associated with abnormal protein folding. The journals major focus points are: etiology, pathogenesis, histopathology, chemical structure, nature of fibrillogenesis; whilst also publishing papers on the basic and chemical genetic aspects of many of these disorders. Amyloid is recognised as one of the leading publications on amyloid protein classifications and the associated disorders, as well as clinical studies on all aspects of amyloid related neurodegenerative diseases and major clinical studies on inherited amyloidosis, especially those related to transthyretin. The Journal also publishes book reviews, meeting reports, editorials, thesis abstracts, review articles and symposia in the various areas listed above.