A qualitative risk assessment of Crimean-Congo haemorrhagic fever in Nigeria: implications for One Health response.

IF 2.3 4区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

International Health Pub Date : 2025-05-27 DOI:10.1093/inthealth/ihaf056

Abiodun Egwuenu, Sunday Makama, Nasir Ahmed, Olanrewaju Igah, Gloria Nwiyi, Yetunde Abioye, Damilola Kolade, Chika Okpala, Chinenye Emelife, Oyeladun Okunromade, Elsie Ilori, Jerry Pantuvo, Emmanuel Agogo, Olusola Aruna, Chinwe Lucia Ochu, Ifedayo M O Adetifa

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引用次数: 0

Abstract

Background: Crimean-Congo Haemorrhagic Fever (CCHF) is a severe tick-borne viral disease. Increasing cases in West Africa suggest potential undetected circulation in Nigeria.

Methods: A One Health Joint Risk Assessment was conducted to identify transmission pathways and assess the likelihood and impact of human CCHF infections at the human-animal-environment interface in Nigeria. Risk framing involved developing structured questions for potential Crimean-Congo Haemorrhagic Fever virus (CCHFV) transmission scenarios. A scoping review was conducted and median seroprevalence values were reported. The likelihood, impact and data uncertainty for human infection scenarios were used for a qualitative estimation of risk.

Results: Human contact with infected livestock during farming, veterinary practices and exposure to ticks was identified as a key infection route. Most cases in Nigeria (66.7%) were identified via serology, with a median human seroprevalence of 6.1% and cattle seroprevalence of 30.2%. CCHFV has been isolated from Rhipicephalus ticks. Four risk assessment questions were defined and focused on veterinarians, abattoir workers, herders, wildlife rangers and healthcare workers. Animal-related professions had a moderate likelihood of infection.

Conclusion: Strengthening One Health surveillance, vector control and multisector infection prevention is crucial to reducing the risk of CCHF and averting future outbreaks.

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尼日利亚克里米亚-刚果出血热的定性风险评估：对One Health反应的影响。

背景：克里米亚-刚果出血热（CCHF）是一种严重的蜱传病毒性疾病。西非不断增加的病例表明尼日利亚可能存在未被发现的传播。方法：开展一项健康联合风险评估，以确定传播途径，并评估尼日利亚人-动物-环境界面人感染CCHF的可能性和影响。风险框架包括为克里米亚-刚果出血热病毒（CCHFV）的潜在传播情景制定结构化问题。进行了范围审查，并报告了中位血清阳性率。人类感染情景的可能性、影响和数据不确定性用于风险的定性估计。结果：人类在养殖、兽医工作和接触蜱虫过程中与感染牲畜的接触被确定为主要感染途径。尼日利亚的大多数病例（66.7%）是通过血清学确定的，人血清阳性率中位数为6.1%，牛血清阳性率中位数为30.2%。已从鼻头蜱中分离出CCHFV。确定了四个风险评估问题，重点是兽医、屠宰场工人、牧民、野生动物护林员和卫生保健工作者。与动物相关的职业有中等程度的感染可能性。结论：加强One Health监测、媒介控制和多部门感染预防对于降低CCHF风险和避免未来暴发至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

4.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： International Health is an official journal of the Royal Society of Tropical Medicine and Hygiene. It publishes original, peer-reviewed articles and reviews on all aspects of global health including the social and economic aspects of communicable and non-communicable diseases, health systems research, policy and implementation, and the evaluation of disease control programmes and healthcare delivery solutions. It aims to stimulate scientific and policy debate and provide a forum for analysis and opinion sharing for individuals and organisations engaged in all areas of global health.