The relationship between periodontitis and proteinuria in chronic kidney disease: A review.

IF 1.8 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Medicina Oral Patologia Oral Y Cirugia Bucal Pub Date : 2025-05-27 DOI:10.4317/medoral.27304

G Zhu, L Chen, Q Liu

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引用次数: 0

Abstract

Background: Proteinuria is elevated protein in the urine possibly progressing to glomerular sclerosis, which was frequently observed in chronic kidney disease (CKD), diabetes, preeclampsia, etc. Previous studies have revealed that periodontitis and these diseases share common risk factors, so a study is necessary to discuss the potential relationship between periodontitis and proteinuria. For the moment, there are no reports that are concerned about the correlation between periodontitis and proteinuria.

Material and methods: We searched PubMed for studies associated with periodontitis and proteinuria published before March 2025.

Results: Existing evidence showed that periodontitis might increase the risk of proteinuria, as periodontal pathogens and periodontal inflammatory reactions were proven to injure the glomerulus and renal tubules contributing to the progression of proteinuria. On the other way, proteinuria might affect systemic inflammation and bone metabolism to increase the risk of periodontitis.

Conclusions: This article reviews the relationship between periodontitis and proteinuria, reveals their predictable potential for chronic kidney injury, and makes recommendations for the treatment of periodontitis and proteinuria.

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慢性肾病患者牙周炎与蛋白尿关系的研究进展。

背景：蛋白尿是尿中蛋白升高，可能进展为肾小球硬化，常见于慢性肾病（CKD）、糖尿病、先兆子痫等。以往的研究表明，牙周炎与这些疾病具有共同的危险因素，因此有必要对牙周炎与蛋白尿的潜在关系进行研究。目前，还没有关于牙周炎和蛋白尿之间关系的报道。材料和方法：我们在PubMed检索了2025年3月之前发表的与牙周炎和蛋白尿相关的研究。结果：现有证据表明，牙周炎可能增加蛋白尿的风险，因为牙周病原体和牙周炎症反应被证明会损伤肾小球和肾小管，从而导致蛋白尿的进展。另一方面，蛋白尿可能会影响全身炎症和骨代谢，从而增加患牙周炎的风险。结论：本文综述了牙周炎和蛋白尿之间的关系，揭示了它们对慢性肾损伤的可预测性，并对牙周炎和蛋白尿的治疗提出了建议。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medicina Oral Patologia Oral Y Cirugia Bucal DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

3-8 weeks

期刊介绍： 1. Oral Medicine and Pathology: Clinicopathological as well as medical or surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, as well as orofacial neurological disorders, and systemic conditions with an impact on the oral cavity. 2. Oral Surgery: Surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, teeth, implants, oral surgical procedures. Surgical management of diseases affecting head and neck areas. 3. Medically compromised patients in Dentistry: Articles discussing medical problems in Odontology will also be included, with a special focus on the clinico-odontological management of medically compromised patients, and considerations regarding high-risk or disabled patients. 4. Implantology 5. Periodontology