Weight-Adjusted Waist Index as a Novel Predictor of Chronic Obstructive Pulmonary Disease: Evidence from NHANES 2013-2018.

IF 2.7 3区医学 Q2 RESPIRATORY SYSTEM

International Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2025-05-22 eCollection Date: 2025-01-01 DOI:10.2147/COPD.S513853

Hongjin Wang, Weiming Chen, Feilong Guo, Zengkai Xu, Xin Luo, Jiahuang Wu, Yong Zhu, Zhisheng Wang

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引用次数: 0

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is a major global health burden. The weight-adjusted waist index (WWI), a novel adiposity metric, may improve COPD risk prediction, but its association remains underexplored.

Methods: Using the National Health and Nutrition Examination Survey (NHANES) 2013-2018 data (n=15,278), we assessed the WWI-COPD relationship via multivariable logistic regression, ROC analysis, and subgroup evaluations.

Results: Higher WWI tertiles correlated with elevated COPD incidence. After full adjustment, each WWI unit increase linked to 70% higher COPD risk (OR=1.70, 95% CI: 1.48-1.95). Participants in the highest quartile of WWI faced a 290% increased risk compared to the lowest quartile (OR=3.90, 95% CI: 2.60-5.86). WWI (AUC=0.707) outperformed BMI (AUC=0.525) and waist circumference (AUC=0.609) in COPD prediction. A nonlinear threshold effect emerged at WWI=12.54. Subgroup analyses confirmed robustness across demographics.

Conclusion: WWI is a simple, cost-effective tool for early COPD detection, outperforming BMI and waist circumference, especially in resource-limited settings, enabling timely intervention and reducing disease burden.

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体重调整腰围指数作为慢性阻塞性肺疾病的新预测因子：来自NHANES 2013-2018的证据

背景：慢性阻塞性肺疾病（COPD）是全球主要的健康负担。体重调整腰围指数（WWI）是一种新的肥胖指标，可以改善COPD风险预测，但其相关性仍未得到充分探讨。方法：利用美国国家健康与营养调查（NHANES） 2013-2018年的数据（n=15,278），通过多变量logistic回归、ROC分析和亚组评估来评估二战与copd的关系。结果：WWI指数升高与COPD发病率升高相关。完全调整后，WWI每增加一个单位，COPD风险增加70% （OR=1.70, 95% CI: 1.48-1.95）。与最低四分位数相比，第一次世界大战中最高四分位数的参与者面临290%的风险增加（OR=3.90, 95% CI: 2.60-5.86）。在COPD预测方面，WWI （AUC=0.707）优于BMI （AUC=0.525）和腰围（AUC=0.609）。在WWI=12.54时出现了非线性阈值效应。亚组分析证实了人口统计学的稳健性。结论：WWI是一种简单、经济的COPD早期检测工具，优于BMI和腰围，特别是在资源有限的情况下，能够及时干预并减轻疾病负担。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Chronic Obstructive Pulmonary Disease RESPIRATORY SYSTEM-

CiteScore

4.80

自引率

10.70%

发文量

372

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed journal of therapeutics and pharmacology focusing on concise rapid reporting of clinical studies and reviews in COPD. Special focus will be given to the pathophysiological processes underlying the disease, intervention programs, patient focused education, and self management protocols. This journal is directed at specialists and healthcare professionals