Effects of Sex and Race on Epidemiology and Comorbidities of Patients with Irritable Bowel Syndrome: A Rome III Era Retrospective Study.

IF 2.9 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Jacqueline Liu, Kathleen Cheng, Yu Lu, Howard Cabral, Horst Christian Weber
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Abstract

Background: Irritable bowel syndrome (IBS) is a prevalent disorder of gut-brain interaction (DGBI) with a negative impact on quality of life and healthcare expenditure. This study aimed to investigate sex-based differences in a large cohort of IBS patients from a multiracial safety-net hospital.

Methods: An electronic query was performed using the International Classification of Diseases, 9th Revision (ICD-9) coding to identify 740 outpatients with IBS between 1 January 2005 and 30 September 2007. Demographic data and ICD-9 coded comorbidities were extracted from electronic records. Data analysis used descriptive statistics and multiple logistic regression analyses.

Results: Comorbid anxiety and depression were significantly more prevalent in female patients (A:24%, p = 0.03; D:29%, p = 0.008) compared with male patients. White female IBS patients had a higher risk for anxiety but not depression compared with non-White patients (p = 0.02). Female sex (p = 0.02), obesity (p = 0.007), and age above fifty (p = 0.02) but not race/ethnicity were significant risk factors for depression. IBS with constipation was more prevalent in female patients (p = 0.005) and in Hispanic compared with non-Hispanic patients (p = 0.03).

Conclusions: Significant sex-based and racial/ethnic differences were identified related to body mass index (BMI), age, and IBS subtypes in this study. Comorbid mood disorders occurred significantly more frequently in female patients, and risk factors for comorbid depression included female sex, older age, and obesity but not race/ethnicity.

性别和种族对肠易激综合征患者流行病学和合并症的影响:罗马III期回顾性研究
背景:肠易激综合征(IBS)是一种常见的肠脑相互作用(DGBI)疾病,对生活质量和医疗保健支出有负面影响。本研究旨在调查来自多种族安全网医院的大队列肠易激综合征患者的性别差异。方法:使用国际疾病分类第9版(ICD-9)编码进行电子查询,确定2005年1月1日至2007年9月30日期间740例肠易激综合征门诊患者。从电子记录中提取人口统计数据和ICD-9编码的合并症。数据分析采用描述性统计和多元逻辑回归分析。结果:女性患者焦虑、抑郁共病发生率较高(A:24%, p = 0.03;D:29%, p = 0.008)。与非白人患者相比,白人女性肠易激综合征患者有更高的焦虑风险,但不存在抑郁风险(p = 0.02)。女性(p = 0.02)、肥胖(p = 0.007)和50岁以上(p = 0.02)是抑郁症的显著危险因素,但种族/民族无关。肠易激综合征合并便秘在女性患者中更为普遍(p = 0.005),在西班牙裔患者中与非西班牙裔患者相比(p = 0.03)。结论:在本研究中发现了与体重指数(BMI)、年龄和IBS亚型相关的显著性别和种族/民族差异。女性患者的共病性情绪障碍发生率明显更高,共病性抑郁症的危险因素包括女性、年龄较大和肥胖,但不包括种族/民族。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
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