[Problem in the Prophylactic Management of Perioperative Venous Thromboembolism(VTE)in Japanese Cancer Patients].

Abstract

In the field of oncological cardiology, the management of venous thromboembolism(VTE)in cancer patients is critical. Cancer patients have a 4-7 fold increased risk of developing VTE compared to non-cancer patients, and once symptomatic pulmonary thromboembolism(PTE)occurs, the mortality rate is high, about 20 according one report. The oncological cardiology guidelines also list future research questions concerning VTE management during chemotherapy. However, cancer patient treatment is not solely pharmacological; particularly in gastrointestinal surgery, operative treatment is crucial, and VTE prophylaxis is important due to the increased incidence during the perioperative period. An important consideration in devising strategies is that there are racial differences in the frequency of VTE occurrences and bleeding tendencies due to anticoagulation therapy. However, data in this field of our country is limited, and currently, Japanese guideline are based on Western guidelines adapted to suit the situation of Japan. Reviewing past data, the risk of VTE in Japanese is generally lower compared to Caucasian populations. In particular, as anticoagulant therapy can also influence postoperative bleeding, its indication requires thorough verification. It is considered one of the crucial challenges in the field of oncological cardiology to construct optimal prophylactic and management methods based on Japanese data moving forward.