[Prediction of Anti-Tumor Immunity-Significance of a Novel Th1-Like CD4+ T-Cell Cluster].

Q4 Medicine
Hiroshi Kagamu
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引用次数: 0

Abstract

Anti-tumor T-cell immunity invigorated by immune checkpoint inhibitors(ICI)mediate anti-tumor effects over the years, resulting in long-term survival. However, the ICI effects vary greatly from patient to patient, and accurate prediction of the effects is still not possible. Long-term anti-tumor T-cell immunity requires that the cancer immunity cycle remain in operation. It is CD4+ T cells that direct the priming, migration and infiltration abilities, and the acquisition of cytolytic functions of CD8+ T cells and drive the cancer immunity cycle. CD4+ T cells undergo functional differentiation called polarization when they are primed in lymph nodes, and they perform their predetermined functions throughout the body. For this reason, the information collected from peripheral blood can reflect the tumor microenvironments. It has been shown in mouse models that CD4+ T cells that polarize into type 1 helper T cells(Th1)are important for anti-tumor immunity. On the other hand, it has been reported that CD4+ T cells that are responsible for the anti-tumor effects of anti-PD-1 antibody and anti-CTLA-4 antibody therapy are Th1-like, but differ from canonical Th1. In this paper, we will discuss the properties of the novel Th1-like CD4+ T-cell cluster discovered by the authors, and the prediction performance of anti-tumor T-cell immunity.

[一种新型th1样CD4+ t细胞群的抗肿瘤免疫预测意义]。
免疫检查点抑制剂(ICI)激活的抗肿瘤t细胞免疫多年来介导抗肿瘤作用,导致长期生存。然而,ICI的效果因患者而异,准确预测其效果仍然是不可能的。长期抗肿瘤t细胞免疫需要肿瘤免疫周期保持运作。CD4+ T细胞指导CD8+ T细胞的启动、迁移和浸润能力,并获得细胞溶解功能,驱动肿瘤免疫周期。当CD4+ T细胞进入淋巴结时,它们会经历被称为极化的功能分化,并在全身执行预定的功能。因此,从外周血中收集的信息可以反映肿瘤微环境。在小鼠模型中已经显示,CD4+ T细胞极化为1型辅助性T细胞(Th1)对抗肿瘤免疫很重要。另一方面,据报道,负责抗pd -1抗体和抗ctla -4抗体治疗的抗肿瘤作用的CD4+ T细胞是Th1样的,但与典型的Th1不同。在本文中,我们将讨论作者发现的新型th1样CD4+ t细胞簇的特性,以及抗肿瘤t细胞免疫的预测性能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
0.20
自引率
0.00%
发文量
337
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