Preferences and willingness to use pre-exposure prophylaxis for HIV among men who have sex with men in mainland China and Hong Kong.

IF 1.8 4区 医学 Q3 INFECTIOUS DISEASES
Sexual health Pub Date : 2025-05-01 DOI:10.1071/SH24247
Jiajun Sun, Jason J Ong, Heather-Marie Schmidt, Curtis Chan, Benjamin R Bavinton, Kimberly Elizabeth Green, Nittaya Phanuphak, Midnight Poonkasetwattana, Nicky Suwandi, Doug Fraser, Weiming Tang, Michael Cassell, Hua Boonyapisomparn, Edmond Pui Hang Choi, Lei Zhang, Warittha Tieosapjaroen
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引用次数: 0

Abstract

Background Pre-exposure prophylaxis (PrEP) uptake remains low in mainland China and Hong Kong. We examined preferences for different PrEP modalities among men who have sex with men (MSM) in mainland China and Hong Kong. Methods We conducted a cross-sectional online survey from May to November 2022 in mainland China and Hong Kong. Eligible participants were aged ≥18years, identified as MSM and self-reported HIV-negative, or unknown HIV status. Random forest models and SHapley Additive exPlanations analyses were used to identify key factors influencing preferences for and willingness to use six PrEP options: (1) daily oral, (2) on-demand oral, (3) monthly oral, (4) two-monthly injectable, (5) six-monthly injectable, and (6) implantable PrEP. Results Among 2142 participants (mainland China: 1604; Hong Kong: 538), the mean age was 28.4 (±7.0) years in mainland China and 34.7 (±9.5) years in Hong Kong. Current PrEP use was similar between mainland China and Hong Kong (18.0% vs 17.8%, P =0.93), with an additional 10.5% and 8.0% reporting past PrEP use (P =0.11), respectively. A greater proportion of participants from mainland China preferred on-demand PrEP compared to those from Hong Kong (55.7% vs 48.1%, P P =0.02). Willingness to use non-oral options was lower, with two-monthly injectable PrEP preferred by 21.1% (19.1-23.1%) in mainland China and 15.4% (12.3-18.5%) in Hong Kong (P Conclusions On-demand and monthly PrEP options remain the preferred choices, though the monthly oral option is neither proven nor available. However, the factors influencing these preferences vary, highlighting the need for tailored and targeted approaches to PrEP implementation.

中国大陆和香港男男性行为者对HIV暴露前预防措施的偏好和意愿
背景:在中国大陆和香港,暴露前预防(PrEP)的使用率仍然很低。我们调查了中国大陆和香港男男性行为者(MSM)对不同PrEP方式的偏好。方法我们于2022年5月至11月在中国大陆和香港进行了横断面在线调查。符合条件的参与者年龄≥18岁,确定为男男性行为者,自我报告HIV阴性或未知HIV状态。使用随机森林模型和SHapley加性解释分析来确定影响PrEP选择的关键因素:(1)每日口服,(2)按需口服,(3)每月口服,(4)2个月注射,(5)6个月注射和(6)植入式PrEP。香港:538岁),中国大陆的平均年龄为28.4(±7.0)岁,香港的平均年龄为34.7(±9.5)岁。中国大陆和香港目前使用PrEP的情况相似(18.0%对17.8%,P =0.93),另有10.5%和8.0%的人报告过去使用PrEP (P =0.11)。来自中国大陆的参与者比来自香港的参与者更喜欢按需PrEP(55.7%比48.1%,P P =0.02)。非口服方案的使用意愿较低,中国大陆21.1%(19.1-23.1%)和香港15.4%(12.3-18.5%)的患者更倾向于2个月注射PrEP。(P)结论按需和每月口服PrEP方案仍然是首选方案,但每月口服PrEP方案既不可靠也不可用。然而,影响这些偏好的因素各不相同,这突出表明需要采取有针对性和针对性的方法来实施预防措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Sexual health
Sexual health 医学-传染病学
CiteScore
2.30
自引率
12.50%
发文量
121
审稿时长
6-12 weeks
期刊介绍: Sexual Health publishes original and significant contributions to the fields of sexual health including HIV/AIDS, Sexually transmissible infections, issues of sexuality and relevant areas of reproductive health. This journal is directed towards those working in sexual health as clinicians, public health practitioners, researchers in behavioural, clinical, laboratory, public health or social, sciences. The journal publishes peer reviewed original research, editorials, review articles, topical debates, case reports and critical correspondence. Officially sponsored by: The Australasian Chapter of Sexual Health Medicine of RACP Sexual Health Society of Queensland Sexual Health is the official journal of the International Union against Sexually Transmitted Infections (IUSTI), Asia-Pacific, and the Asia-Oceania Federation of Sexology.
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