Jiajun Sun, Jason J Ong, Heather-Marie Schmidt, Curtis Chan, Benjamin R Bavinton, Kimberly Elizabeth Green, Nittaya Phanuphak, Midnight Poonkasetwattana, Nicky Suwandi, Doug Fraser, Weiming Tang, Michael Cassell, Hua Boonyapisomparn, Edmond Pui Hang Choi, Lei Zhang, Warittha Tieosapjaroen
{"title":"Preferences and willingness to use pre-exposure prophylaxis for HIV among men who have sex with men in mainland China and Hong Kong.","authors":"Jiajun Sun, Jason J Ong, Heather-Marie Schmidt, Curtis Chan, Benjamin R Bavinton, Kimberly Elizabeth Green, Nittaya Phanuphak, Midnight Poonkasetwattana, Nicky Suwandi, Doug Fraser, Weiming Tang, Michael Cassell, Hua Boonyapisomparn, Edmond Pui Hang Choi, Lei Zhang, Warittha Tieosapjaroen","doi":"10.1071/SH24247","DOIUrl":null,"url":null,"abstract":"<p><p>Background Pre-exposure prophylaxis (PrEP) uptake remains low in mainland China and Hong Kong. We examined preferences for different PrEP modalities among men who have sex with men (MSM) in mainland China and Hong Kong. Methods We conducted a cross-sectional online survey from May to November 2022 in mainland China and Hong Kong. Eligible participants were aged ≥18years, identified as MSM and self-reported HIV-negative, or unknown HIV status. Random forest models and SHapley Additive exPlanations analyses were used to identify key factors influencing preferences for and willingness to use six PrEP options: (1) daily oral, (2) on-demand oral, (3) monthly oral, (4) two-monthly injectable, (5) six-monthly injectable, and (6) implantable PrEP. Results Among 2142 participants (mainland China: 1604; Hong Kong: 538), the mean age was 28.4 (±7.0) years in mainland China and 34.7 (±9.5) years in Hong Kong. Current PrEP use was similar between mainland China and Hong Kong (18.0% vs 17.8%, P =0.93), with an additional 10.5% and 8.0% reporting past PrEP use (P =0.11), respectively. A greater proportion of participants from mainland China preferred on-demand PrEP compared to those from Hong Kong (55.7% vs 48.1%, P P =0.02). Willingness to use non-oral options was lower, with two-monthly injectable PrEP preferred by 21.1% (19.1-23.1%) in mainland China and 15.4% (12.3-18.5%) in Hong Kong (P Conclusions On-demand and monthly PrEP options remain the preferred choices, though the monthly oral option is neither proven nor available. However, the factors influencing these preferences vary, highlighting the need for tailored and targeted approaches to PrEP implementation.</p>","PeriodicalId":22165,"journal":{"name":"Sexual health","volume":"22 ","pages":""},"PeriodicalIF":1.8000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sexual health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1071/SH24247","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0
Abstract
Background Pre-exposure prophylaxis (PrEP) uptake remains low in mainland China and Hong Kong. We examined preferences for different PrEP modalities among men who have sex with men (MSM) in mainland China and Hong Kong. Methods We conducted a cross-sectional online survey from May to November 2022 in mainland China and Hong Kong. Eligible participants were aged ≥18years, identified as MSM and self-reported HIV-negative, or unknown HIV status. Random forest models and SHapley Additive exPlanations analyses were used to identify key factors influencing preferences for and willingness to use six PrEP options: (1) daily oral, (2) on-demand oral, (3) monthly oral, (4) two-monthly injectable, (5) six-monthly injectable, and (6) implantable PrEP. Results Among 2142 participants (mainland China: 1604; Hong Kong: 538), the mean age was 28.4 (±7.0) years in mainland China and 34.7 (±9.5) years in Hong Kong. Current PrEP use was similar between mainland China and Hong Kong (18.0% vs 17.8%, P =0.93), with an additional 10.5% and 8.0% reporting past PrEP use (P =0.11), respectively. A greater proportion of participants from mainland China preferred on-demand PrEP compared to those from Hong Kong (55.7% vs 48.1%, P P =0.02). Willingness to use non-oral options was lower, with two-monthly injectable PrEP preferred by 21.1% (19.1-23.1%) in mainland China and 15.4% (12.3-18.5%) in Hong Kong (P Conclusions On-demand and monthly PrEP options remain the preferred choices, though the monthly oral option is neither proven nor available. However, the factors influencing these preferences vary, highlighting the need for tailored and targeted approaches to PrEP implementation.
期刊介绍:
Sexual Health publishes original and significant contributions to the fields of sexual health including HIV/AIDS, Sexually transmissible infections, issues of sexuality and relevant areas of reproductive health. This journal is directed towards those working in sexual health as clinicians, public health practitioners, researchers in behavioural, clinical, laboratory, public health or social, sciences. The journal publishes peer reviewed original research, editorials, review articles, topical debates, case reports and critical correspondence.
Officially sponsored by:
The Australasian Chapter of Sexual Health Medicine of RACP
Sexual Health Society of Queensland
Sexual Health is the official journal of the International Union against Sexually Transmitted Infections (IUSTI), Asia-Pacific, and the Asia-Oceania Federation of Sexology.