{"title":"TIR-mediated immune signaling through the EDS1:PAD4:ADR1 node is conserved in monocots and dicots.","authors":"Natsumi Maruta, Mitchell Sorbello, Bostjan Kobe","doi":"10.1016/j.molp.2024.12.017","DOIUrl":null,"url":null,"abstract":"<p><p>Plants defend themselves against pathogens by activating two interconnected layers of immunity: pattern- and effector-triggered immunity. Recent studies shed light on a number of unanswered questions in these pathways and demonstrate a conserved structural basis, in monocots and dicots, of signaling through the EDS1:PAD4:ADR1 module, downstream of Toll/interleukin-1 receptor (TIR) domain-containing immune receptors that cleave the dinucleotide nicotinamide adenine dinucleotide (NAD<sup>+</sup>). The studies define a new function for TIR domain proteins in monocots and suggest that the signaling molecule 5″-phosphoribosyl (pRib)-AMP is derived from the TIR product 2'-adenosine diphosphate ribose (2'cADPR). These findings have important implications for developing the strategies to breed resistant crops.</p>","PeriodicalId":19012,"journal":{"name":"Molecular Plant","volume":"18 2","pages":"192-194"},"PeriodicalIF":24.1000,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Plant","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.molp.2024.12.017","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/31 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Plants defend themselves against pathogens by activating two interconnected layers of immunity: pattern- and effector-triggered immunity. Recent studies shed light on a number of unanswered questions in these pathways and demonstrate a conserved structural basis, in monocots and dicots, of signaling through the EDS1:PAD4:ADR1 module, downstream of Toll/interleukin-1 receptor (TIR) domain-containing immune receptors that cleave the dinucleotide nicotinamide adenine dinucleotide (NAD+). The studies define a new function for TIR domain proteins in monocots and suggest that the signaling molecule 5″-phosphoribosyl (pRib)-AMP is derived from the TIR product 2'-adenosine diphosphate ribose (2'cADPR). These findings have important implications for developing the strategies to breed resistant crops.
期刊介绍：
Molecular Plant is dedicated to serving the plant science community by publishing novel and exciting findings with high significance in plant biology. The journal focuses broadly on cellular biology, physiology, biochemistry, molecular biology, genetics, development, plant-microbe interaction, genomics, bioinformatics, and molecular evolution.
Molecular Plant publishes original research articles, reviews, Correspondence, and Spotlights on the most important developments in plant biology.
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