Breast Cancer Characteristics after Metabolic and Bariatric Surgery: A Matched Comparison to Patients with Severe Obesity.

IF 2.9 3区医学 Q1 SURGERY

Obesity Surgery Pub Date : 2025-05-27 DOI:10.1007/s11695-025-07916-3

Jawad Tome, Marian Khatib, Eran Nizri, Lilah Margalit Grigg, Lior Orbach, Guy Lahat, Shai Meron Eldar, Adam Abu-Abeid

{"title":"Breast Cancer Characteristics after Metabolic and Bariatric Surgery: A Matched Comparison to Patients with Severe Obesity.","authors":"Jawad Tome, Marian Khatib, Eran Nizri, Lilah Margalit Grigg, Lior Orbach, Guy Lahat, Shai Meron Eldar, Adam Abu-Abeid","doi":"10.1007/s11695-025-07916-3","DOIUrl":null,"url":null,"abstract":"Background: Severe obesity increases breast cancer (BC) risk and progression. Metabolic and Bariatric Surgery (MBS) modulates metabolic and hormonal pathways, potentially influencing cancer biology. This study evaluates BC patients after MBS. The aim of this study is to assess the impact of MBS on BC, focusing on disease-free survival (DFS), presentation, subtypes, and oncologic outcomes.Methods: A retrospective analysis of a single-center database included patients undergoing BC surgery after MBS (2012-2020), matched (1:4) to patients with severe obesity undergoing BC surgery.Results: Among 696 patients, 29 (4%) had BC post-MBS. Sleeve gastrectomy was the most common procedure (48.2%). Mean age at BC surgery was 60.7 ± 10 years. BMI prior to BC surgery was lower in the MBS-group (32.4 vs. 38.3 kg/m2, p < 0.0001). Disease-free survival (114 vs. 146 months, p = 0.75) and recurrence rates were similar. The MBS-group had lower luminal-A subtype rates (34.4% vs. 59.5%, p = 0.01) and higher luminal-B subtype rates (58.6% vs. 27.6%, p = 0.001). No patients in the MBS-group had ductal carcinoma in situ (DCIS) (0% vs. 20%, p = 0.03). Other subtypes showed no differences.Conclusion: MBS may influence BC pathogenesis, with lower DCIS and luminal-A rates. These findings suggest a potential reduction in overall BC incidence due to metabolic and hormonal changes after MBS. Oncologic outcomes remained comparable.","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Obesity Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11695-025-07916-3","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"SURGERY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Severe obesity increases breast cancer (BC) risk and progression. Metabolic and Bariatric Surgery (MBS) modulates metabolic and hormonal pathways, potentially influencing cancer biology. This study evaluates BC patients after MBS. The aim of this study is to assess the impact of MBS on BC, focusing on disease-free survival (DFS), presentation, subtypes, and oncologic outcomes.

Methods: A retrospective analysis of a single-center database included patients undergoing BC surgery after MBS (2012-2020), matched (1:4) to patients with severe obesity undergoing BC surgery.

Results: Among 696 patients, 29 (4%) had BC post-MBS. Sleeve gastrectomy was the most common procedure (48.2%). Mean age at BC surgery was 60.7 ± 10 years. BMI prior to BC surgery was lower in the MBS-group (32.4 vs. 38.3 kg/m², p < 0.0001). Disease-free survival (114 vs. 146 months, p = 0.75) and recurrence rates were similar. The MBS-group had lower luminal-A subtype rates (34.4% vs. 59.5%, p = 0.01) and higher luminal-B subtype rates (58.6% vs. 27.6%, p = 0.001). No patients in the MBS-group had ductal carcinoma in situ (DCIS) (0% vs. 20%, p = 0.03). Other subtypes showed no differences.

Conclusion: MBS may influence BC pathogenesis, with lower DCIS and luminal-A rates. These findings suggest a potential reduction in overall BC incidence due to metabolic and hormonal changes after MBS. Oncologic outcomes remained comparable.

查看原文本刊更多论文

代谢和减肥手术后的乳腺癌特征：与严重肥胖患者的匹配比较。

背景：严重肥胖增加乳腺癌（BC）的风险和进展。代谢和减肥手术（MBS）调节代谢和激素途径，潜在地影响癌症生物学。本研究对MBS后的BC患者进行评估。本研究的目的是评估MBS对BC的影响，重点关注无病生存（DFS）、表现、亚型和肿瘤学结局。方法：对单中心数据库进行回顾性分析，纳入MBS术后接受BC手术的患者（2012-2020），与接受BC手术的重度肥胖患者（1:4）匹配。结果：696例患者中，29例（4%）发生mbs后BC。袖式胃切除术是最常见的手术（48.2%）。BC手术的平均年龄为60.7±10岁。MBS组BC手术前BMI较低（32.4 vs 38.3 kg/m2）， p结论：MBS可能影响BC发病机制，DCIS和luminal-A发生率较低。这些发现表明，由于MBS后代谢和激素的变化，总体BC发病率可能会降低。肿瘤结果保持可比性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Obesity Surgery 医学-外科

CiteScore

5.80

自引率

24.10%

发文量

567

审稿时长

3-6 weeks

期刊介绍： Obesity Surgery is the official journal of the International Federation for the Surgery of Obesity and metabolic disorders (IFSO). A journal for bariatric/metabolic surgeons, Obesity Surgery provides an international, interdisciplinary forum for communicating the latest research, surgical and laparoscopic techniques, for treatment of massive obesity and metabolic disorders. Topics covered include original research, clinical reports, current status, guidelines, historical notes, invited commentaries, letters to the editor, medicolegal issues, meeting abstracts, modern surgery/technical innovations, new concepts, reviews, scholarly presentations and opinions. Obesity Surgery benefits surgeons performing obesity/metabolic surgery, general surgeons and surgical residents, endoscopists, anesthetists, support staff, nurses, dietitians, psychiatrists, psychologists, plastic surgeons, internists including endocrinologists and diabetologists, nutritional scientists, and those dealing with eating disorders.