The effect of low-level laser therapy after rapid maxillary expansion: Micro-CT analysis.

IF 2.1 4区医学 Q3 ENGINEERING, BIOMEDICAL

Lasers in Medical Science Pub Date : 2025-05-27 DOI:10.1007/s10103-025-04497-6

Maria Bernadete Sasso Stuani, Andréa Sasso Stuani, Gabriela Leite Pedroso, Paôla Caroline da Silva Mira, Sara Gollino, Michel Dastra, Birte Melsen

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Abstract

This study aimed to evaluate quantitatively the effects of low-level laser therapy (LLLT) on bone healing performed after rapid maxillary expansion (RME) in rats, using micro-computed tomography (micro-CT). Ninety rats were used, randomly distributed into three groups: control (n = 10) (young and adult rats - intact suture), experimental I (n = 40) (young and adult rats with RME without LLLT), and experimental II (n = 40) (young and adult rats with RME + LLLT). Five rats from the groups were euthanized on days 0, 7, 14, and 21 of the experiment and evaluated by microCT analysis. The laser increased the bone formation volume at 7 and 14 days (young rats) and 14 days (adult rats) were statistically significant (p < 0.05), but at the end of the healing (21 days), no statistically significant difference was observed between the laser and no-laser groups (p > 0.05). These findings suggest that LLLT improves bone mineralization during the early healing phases after RME, accelerating the process of bone mineralization during the initial experimental phase, which may have clinical implications in reducing orthodontic treatment duration and improving bone stability.

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上颌快速扩张术后低水平激光治疗的效果：显微ct分析。

本研究旨在定量评估低水平激光治疗（LLLT）对大鼠快速上颌扩张（RME）后骨愈合的影响，采用微计算机断层扫描（micro-CT）。选用90只大鼠，随机分为3组：对照组（n = 10）（幼龄和成年大鼠-缝合完好）、实验I组（n = 40）（幼龄和成年RME + LLLT大鼠）和实验II组（n = 40）（RME + LLLT幼龄和成年大鼠）。分别于实验第0、7、14、21天对各组5只大鼠实施安乐死，并进行显微ct分析。激光在7、14天（幼鼠）和14天（成年大鼠）的骨形成体积增加有统计学意义（p 0.05）。这些结果表明，LLLT可以改善RME术后早期愈合阶段的骨矿化，加速实验初期的骨矿化过程，这可能对缩短正畸治疗时间和提高骨稳定性具有临床意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lasers in Medical Science 医学-工程：生物医学

CiteScore

4.50

自引率

4.80%

发文量

192

审稿时长

3-8 weeks

期刊介绍： Lasers in Medical Science (LIMS) has established itself as the leading international journal in the rapidly expanding field of medical and dental applications of lasers and light. It provides a forum for the publication of papers on the technical, experimental, and clinical aspects of the use of medical lasers, including lasers in surgery, endoscopy, angioplasty, hyperthermia of tumors, and photodynamic therapy. In addition to medical laser applications, LIMS presents high-quality manuscripts on a wide range of dental topics, including aesthetic dentistry, endodontics, orthodontics, and prosthodontics. The journal publishes articles on the medical and dental applications of novel laser technologies, light delivery systems, sensors to monitor laser effects, basic laser-tissue interactions, and the modeling of laser-tissue interactions. Beyond laser applications, LIMS features articles relating to the use of non-laser light-tissue interactions.