Clinicopathological Features of Non-Small Cell Lung Carcinoma with NRAS Mutation.

IF 3 3区 医学 Q2 HEALTH CARE SCIENCES & SERVICES
Andrea Ambrosini-Spaltro, Claudia Rengucci, Laura Capelli, Elisa Chiadini, Chiara Bennati, Angelo Delmonte, Silvia Vecchiarelli, Francesco Limarzi, Sofia Nosseir, Graziana Gallo, Mirca Valli, Paola Ulivi, Daniele Calistri
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引用次数: 0

Abstract

(1) Background: NRAS mutations affect fewer than 1% of lung adenocarcinomas. The aim of this study was to describe the clinicopathological features of lung carcinomas with NRAS mutations. (2) Methods: A series of NRAS-mutated lung carcinomas was collected from a molecular diagnostic unit (from four hospitals). The cases were analyzed with next-generation sequencing. A log-rank test for overall survival (OS) was calculated. (3) Results: NRAS mutations were detected in 14/1948 samples (0.72%) of non-small-cell lung carcinomas from 13 patients (8 males, 5 females). NRAS mutations involved codon 61 in the majority (9/13, 69.2%) of cases. The other NRAS mutations affected codon 12 (2/13, 15.4%), codon 13 (1/13, 7.7%), and codon 142 (1/13, 7.7%). In 7/13 cases, co-alterations in additional genes were also present. Pleomorphic/sarcomatoid features were identified in 3/13 (23.1%) cases, in 2/8 (25.0%) histological specimens, and in 2/5 (40.0%) surgical specimens, respectively. Follow-up data were available in 11/13 cases, with 6 patients deceased. By a log-rank test, patients with NRAS mutations in codon 61 had a better outcome (estimated mean of 32.6 ± 7.1 months) compared to those with other NRAS mutations (estimated mean of 8.7 ± 4.4 months), with a significant difference (p = 0.048 for OS). (4) Conclusions: Lung carcinomas with NRAS mutation may display pleomorphic or sarcomatoid features. Mutations in codon 61 showed a more favorable prognosis than those in other codons.

NRAS突变的非小细胞肺癌的临床病理特征。
(1)背景:NRAS突变影响不到1%的肺腺癌。本研究的目的是描述NRAS突变肺癌的临床病理特征。(2)方法:从某分子诊断单位(4家医院)收集一系列nras突变肺癌病例。采用新一代测序对病例进行分析。计算总生存期(OS)的log-rank检验。(3)结果:13例非小细胞肺癌患者(男8例,女5例)中14/1948例(0.72%)检测到NRAS突变。NRAS突变主要涉及密码子61(9/13,69.2%)。其他NRAS突变影响密码子12(2/ 13,15.4%)、密码子13(1/ 13,7.7%)和密码子142(1/ 13,7.7%)。在7/13的病例中,其他基因也存在共改变。3/13例(23.1%)、2/8例(25.0%)的组织学标本和2/5例(40.0%)的手术标本分别有多形性/肉瘤样特征。11/13例有随访资料,6例死亡。通过log-rank检验,密码子61 NRAS突变患者的预后(估计平均为32.6±7.1个月)优于其他NRAS突变患者(估计平均为8.7±4.4个月),差异有统计学意义(OS p = 0.048)。(4)结论:NRAS突变的肺癌可表现为多形性或肉瘤样特征。密码子61突变比其他密码子突变预后更好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Personalized Medicine
Journal of Personalized Medicine Medicine-Medicine (miscellaneous)
CiteScore
4.10
自引率
0.00%
发文量
1878
审稿时长
11 weeks
期刊介绍: Journal of Personalized Medicine (JPM; ISSN 2075-4426) is an international, open access journal aimed at bringing all aspects of personalized medicine to one platform. JPM publishes cutting edge, innovative preclinical and translational scientific research and technologies related to personalized medicine (e.g., pharmacogenomics/proteomics, systems biology). JPM recognizes that personalized medicine—the assessment of genetic, environmental and host factors that cause variability of individuals—is a challenging, transdisciplinary topic that requires discussions from a range of experts. For a comprehensive perspective of personalized medicine, JPM aims to integrate expertise from the molecular and translational sciences, therapeutics and diagnostics, as well as discussions of regulatory, social, ethical and policy aspects. We provide a forum to bring together academic and clinical researchers, biotechnology, diagnostic and pharmaceutical companies, health professionals, regulatory and ethical experts, and government and regulatory authorities.
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