Injectable Stem Cell-Based Therapies for Myocardial Regeneration: A Review of the Literature.

IF 5 3区医学 Q1 ENGINEERING, BIOMEDICAL

Journal of Functional Biomaterials Pub Date : 2025-04-23 DOI:10.3390/jfb16050152

Marissa Guo, Tatsuya Watanabe, Toshiharu Shinoka

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Abstract

Stem cell-based therapies are an emerging treatment modality aimed at replenishing lost cardiomyocytes and improving myocardial function after cardiac injury. This review examines the current state of research on injectable stem cell therapies in the setting of cardiovascular disease given their relative simplicity and ability for deep myocardial tissue penetration. Various methods of cell delivery, ranging in level of invasiveness and procedural complexity, have been developed, and numerous cell types have been studied as potential sources of stem cells, each with distinct advantages and disadvantages. We discuss key challenges associated with this approach, including low stem cell retention after transplantation and the innovative biomolecular strategies that have been explored to address this issue. Overall, investigations into the application of stem cells toward cardiac regeneration remain predominantly in the preclinical stage with a number of small, early-phase clinical trials. However, continued scientific advancements in stem cell technology may provide transformative treatment options for patients with heart failure, offering improved survival and quality of life.

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可注射干细胞治疗心肌再生：文献综述。

干细胞治疗是一种新兴的治疗方式，旨在补充心脏损伤后失去的心肌细胞和改善心肌功能。本文综述了注射干细胞治疗心血管疾病的研究现状，因为它们相对简单，能够深入心肌组织。各种各样的细胞递送方法，在侵入性和程序复杂性的水平范围内，已经开发出来，许多细胞类型已经被研究作为干细胞的潜在来源，每种细胞都有不同的优点和缺点。我们讨论了与这种方法相关的关键挑战，包括移植后低干细胞保留率和已经探索的解决这一问题的创新生物分子策略。总的来说，对干细胞在心脏再生中的应用的研究仍主要处于临床前阶段，有许多小型的早期临床试验。然而，干细胞技术的持续科学进步可能为心力衰竭患者提供变革性的治疗选择，提高生存率和生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Functional Biomaterials Engineering-Biomedical Engineering

CiteScore

4.60

自引率

4.20%

发文量

226

审稿时长

11 weeks

期刊介绍： Journal of Functional Biomaterials (JFB, ISSN 2079-4983) is an international and interdisciplinary scientific journal that publishes regular research papers (articles), reviews and short communications about applications of materials for biomedical use. JFB covers subjects from chemistry, pharmacy, biology, physics over to engineering. The journal focuses on the preparation, performance and use of functional biomaterials in biomedical devices and their behaviour in physiological environments. Our aim is to encourage scientists to publish their results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Several topical special issues will be published. Scope: adhesion, adsorption, biocompatibility, biohybrid materials, bio-inert materials, biomaterials, biomedical devices, biomimetic materials, bone repair, cardiovascular devices, ceramics, composite materials, dental implants, dental materials, drug delivery systems, functional biopolymers, glasses, hyper branched polymers, molecularly imprinted polymers (MIPs), nanomedicine, nanoparticles, nanotechnology, natural materials, self-assembly smart materials, stimuli responsive materials, surface modification, tissue devices, tissue engineering, tissue-derived materials, urological devices.