Global research trends on endoplasmic reticulum stress in retinal diseases from 2000 to 2024.

IF 1.4 4区医学 Q3 OPHTHALMOLOGY

International Ophthalmology Pub Date : 2025-05-26 DOI:10.1007/s10792-025-03584-5

Weiwen Hu, Yahan Tu, Jian Tan, Yeting Lin, Yicang Wang, Qiong Zhou

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引用次数: 0

Abstract

Purpose: To comprehensively explore global research trends on endoplasmic reticulum stress (ERS) in retinal diseases over the past 24 years.

Methods: An analysis of 917 publications from the Web of Science Core Collection, spanning from 1 January 2000 to 15 April 2024, was conducted to explore ERS research in retinal diseases. Bibliometric and visualisation software was employed to identify key contributors and research trends.

Results: Hideaki Hara and Sarah X. Zhang were identified as the most published and most cited authors, respectively. The United States led in both publications and citations. Sun Yat-sen University ranked highest in publications, while the University of Oklahoma received the most citations. Investigative Ophthalmology & Visual Science was the leading journal in both publications and citations. A total of 108 of the 1385 author keywords, each occurring five or more times, clustered into four major themes: retinal photoreceptor degeneration, glaucoma and optic nerve damage, diabetic retinopathy and age-related macular degeneration. Keywords such as "in vivo", "dominant retinitis pigmentosa", "endothelial growth factor", "molecular", and "quality control" displayed the strongest citation bursts. ERS research (2000 ~ 2024) has evolved from retinal neuroprotection to include specific cell types and diseases, explored signalling pathways and therapeutic mechanisms, and more recently has focused on molecular insights and gene therapy applications.

Conclusion: This bibliometric analysis highlighted significant growth in publications on ERS in retinal diseases, reflecting an increasing scholarly focus. ERS represents a potential target for exploring pathological changes in retinal neuro-microvascular and related disorders, warranting further investigation.

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2000 - 2024年视网膜疾病内质网应激的全球研究趋势。

目的：全面探讨近24年来视网膜疾病内质网应激（ERS）的全球研究趋势。方法：对Web of Science Core Collection 2000年1月1日至2024年4月15日的917篇出版物进行分析，探讨ERS在视网膜疾病中的研究。采用文献计量和可视化软件来确定关键贡献者和研究趋势。结果：Hideaki Hara和Sarah X. Zhang分别被确定为发表次数最多和被引次数最多的作者。美国在出版物和引用方面都处于领先地位。中山大学在发表论文方面排名最高，而俄克拉荷马大学被引用次数最多。《调查眼科学与视觉科学》杂志在出版物和引用量方面都处于领先地位。1385个作者关键词中有108个，每个关键词出现5次或5次以上，聚在4个主要主题中：视网膜光感受器变性、青光眼和视神经损伤、糖尿病视网膜病变和年龄相关性黄斑变性。“体内”、“显性色素性视网膜炎”、“内皮生长因子”、“分子”、“质量控制”等关键词被引用次数最多。ERS研究（2000 ~ 2024）从视网膜神经保护发展到包括特定的细胞类型和疾病，探索信号通路和治疗机制，最近主要集中在分子见解和基因治疗应用。结论：这一文献计量学分析强调了视网膜疾病中ERS出版物的显著增长，反映了越来越多的学术关注。ERS是研究视网膜神经微血管病变及相关疾病的潜在靶点，值得进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Ophthalmology OPHTHALMOLOGY-

CiteScore

3.20

自引率

0.00%

发文量

451

期刊介绍： International Ophthalmology provides the clinician with articles on all the relevant subspecialties of ophthalmology, with a broad international scope. The emphasis is on presentation of the latest clinical research in the field. In addition, the journal includes regular sections devoted to new developments in technologies, products, and techniques.