Katharina Gelles, Maria Butylina, Peter Pietschmann
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引用次数: 0
Abstract
Background: Osteoporosis is a frequent age-related skeletal disorder, wielding an enormous influence on the quality of life of many women, but also men. Osteoporosis results from a shifted ratio between the activity of osteoblasts and osteoclasts resulting in an increased degradation of bone. This leads to a systemic impairment of bone mass and microarchitecture. Currently only a small number of patients with osteoporosis is treated adequately, making the disease an enormous economic burden. This implies the urgent need of developing new treatment strategies and application mechanisms. Therefore, animal models are of great importance for the investigation and treatment of bone diseases.
Summary: In this narrative review we focus on animal models specially used for age-related osteoporosis including mice, fish and large animal models.
Key message: With this manuscript we want to contribute to the identification of novel treatment strategies for the treatment of age-related osteoporosis.
期刊介绍：
In view of the ever-increasing fraction of elderly people, understanding the mechanisms of aging and age-related diseases has become a matter of urgent necessity. ''Gerontology'', the oldest journal in the field, responds to this need by drawing topical contributions from multiple disciplines to support the fundamental goals of extending active life and enhancing its quality. The range of papers is classified into four sections. In the Clinical Section, the aetiology, pathogenesis, prevention and treatment of agerelated diseases are discussed from a gerontological rather than a geriatric viewpoint. The Experimental Section contains up-to-date contributions from basic gerontological research. Papers dealing with behavioural development and related topics are placed in the Behavioural Science Section. Basic aspects of regeneration in different experimental biological systems as well as in the context of medical applications are dealt with in a special section that also contains information on technological advances for the elderly. Providing a primary source of high-quality papers covering all aspects of aging in humans and animals, ''Gerontology'' serves as an ideal information tool for all readers interested in the topic of aging from a broad perspective.
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