Insulin resistance assessed by estimated glucose disposal rate and the risk of abdominal aortic calcification: findings from a nationwide cohort study.

IF 3.9 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Frontiers in Endocrinology Pub Date : 2025-05-12 eCollection Date: 2025-01-01 DOI:10.3389/fendo.2025.1560577

Bo Zhao, Zongliang Yu, Fengyan Tang, Zhenqin Feng, Junfeng Wang, Zhaoxiang Wang

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引用次数: 0

Abstract

Purpose: The estimated glucose disposal rate (eGDR) serves as a straightforward and noninvasive indicator of insulin resistance (IR). This study aims to explore the association between eGDR and the risk of abdominal aortic calcification (AAC).

Methods: We utilized data from adult participants (≥40 years old, n=3006) from the 2013-2014 National Health and Nutrition Examination Survey (NHANES) database. AAC was measured by dual-energy X-ray absorptiometry and quantified using the Kauppila score. Severe AAC (SAAC) was defined as an AAC score > 6. Logistic regression, restricted cubic spline (RCS), and subgroup analysis were used to analyze the relationship between eGDR and SAAC risk.

Results: In fully adjusted models, eGDR was found to be negatively associated with SAAC (OR=0.86, 95%CI:0.79-0.94, P<0.001). Compared to participants in the lowest eGDR quantile, those in the highest quantile exhibited a lower risk of SAAC (OR=0.47, 95%CI:0.25-0.91, P=0.026). The RCS analysis indicates a nonlinear relationship between eGDR and SAAC risk, with a turning point at 7.05 mg/kg/min. Subgroup analysis showed that the association between eGDR and SAAC risk was more significant in women.

Conclusions: The degree of IR assessed by eGDR is associated with SAAC risk. The eGDR shows promise as an epidemiological tool for evaluating the influence of IR on AAC.

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通过估计葡萄糖处置率和腹主动脉钙化风险评估胰岛素抵抗：来自一项全国性队列研究的发现。

目的：估计葡萄糖处置率（eGDR）可作为胰岛素抵抗（IR）的直接无创指标。本研究旨在探讨eGDR与腹主动脉钙化（AAC）风险之间的关系。方法：我们使用2013-2014年国家健康与营养检查调查（NHANES）数据库中成人参与者（≥40岁，n=3006）的数据。AAC采用双能x线吸收仪测量，并用Kauppila评分进行量化。重度AAC （Severe AAC， SAAC）定义为AAC评分bb0.6。采用Logistic回归、限制性三次样条（RCS）和亚组分析分析eGDR与SAAC风险的关系。结果：在完全调整的模型中，eGDR与SAAC呈负相关（OR=0.86, 95%CI:0.79-0.94， PP=0.026）。RCS分析显示eGDR与SAAC风险之间存在非线性关系，转折点为7.05 mg/kg/min。亚组分析显示eGDR与SAAC风险之间的关联在女性中更为显著。结论：eGDR评估的IR程度与SAAC风险相关。eGDR有望成为评估IR对AAC影响的流行病学工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Endocrinology Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

5.70

自引率

9.60%

发文量

3023

审稿时长

14 weeks

期刊介绍： Frontiers in Endocrinology is a field journal of the "Frontiers in" journal series. In today’s world, endocrinology is becoming increasingly important as it underlies many of the challenges societies face - from obesity and diabetes to reproduction, population control and aging. Endocrinology covers a broad field from basic molecular and cellular communication through to clinical care and some of the most crucial public health issues. The journal, thus, welcomes outstanding contributions in any domain of endocrinology. Frontiers in Endocrinology publishes articles on the most outstanding discoveries across a wide research spectrum of Endocrinology. The mission of Frontiers in Endocrinology is to bring all relevant Endocrinology areas together on a single platform.