Synthesis and Evaluation of Trehalose-Based Mertansine Warheads for Bacillus Calmette-Guérin Delivery of Anticancer Agents.

IF 2.8 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

ChemBioChem Pub Date : 2025-05-27 DOI:10.1002/cbic.202500390

Michael Grimmeisen, Xuan Wang, Melissa Weldle, Kerstin Sartory, Sara Benkhelifa, Yu Zhang, Trinh Dao, Jonas Meyer, Oliver Gorka, Olaf Groß, Claudia Jessen-Trefzer

引用次数: 0

Abstract

Nonmuscle invasive bladder cancer (NMIBC) accounts for 75% of bladder cancer cases, with Bacillus Calmette-Guérin (BCG) immunotherapy as the gold standard for high-risk patients. BCG elicits a robust immune response but is limited by adverse effects and resistance. To enhance its efficacy, a trehalose-based conjugation strategy is developed, tethering a cytostatic agent to BCG via a cleavable disulfide linker. This system enables selective drug integration into the BCG envelope and controlled release in tumor cells, aiming to improve therapeutic precision while minimizing toxicity. This approach combines immunotherapy with targeted chemotherapy, offering a promising strategy for NMIBC treatment.

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用于BCG抗癌药物递送的海藻糖Mertansine战斗部的合成与评价。

非肌肉浸润性膀胱癌（NMIBC）占膀胱癌病例的75%，卡介苗（BCG）免疫治疗是高危患者的金标准。卡介苗引起强烈的免疫反应，但受到不良反应和耐药性的限制。为了提高其功效，我们开发了一种基于海藻糖的偶联策略，通过可切割的二硫连接剂将细胞抑制剂拴在BCG上。该系统能够选择性地将药物整合到BCG包膜中，并在肿瘤细胞中控制释放，旨在提高治疗精度，同时最小化毒性。这种方法将免疫治疗与靶向化疗相结合，为NMIBC治疗提供了一种有希望的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ChemBioChem 生物-生化与分子生物学

CiteScore

6.10

自引率

3.10%

发文量

407

审稿时长

1 months

期刊介绍： ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).