Daniel de Luis, David Primo, Olatz Izaola, Juan José López Gómez
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引用次数: 0
Abstract
Introduction: Sarcopenia is a condition characterized by muscle mass loss. Some investigations have demonstrated the role of Brain-derived neurotrophic factor (BDNF) as a protector against the presence of sarcopenia in patients with chronic kidney disease.
Objective: We aimed to explore the role of circu-lating BDNF in the development of sarcopenia among individuals with disease-related malnutrition (DRM).
Material and methods: A total of 160 patients di-agnosed with DRM according to the Global Leadership Initiative on Malnutrition (GLIM) criteria were enrolled. Anthropometric data, muscle mass assessed via ultrasound at the rectus femoris quadriceps (RFQ) level, bioelectrical imped-ance analysis (skeletal muscle mass (SMM), appendicular skeletal muscle mass (aSMM), and appendicular skeletal muscle mass index (aSMMI)), hand-grip strength, biochemical parameters, dietary intake, and circulating levels of BDNF were measured.
Results: A total of 55 patients (34.4%) were classified as sarcopenic, while 105 patients (65.6%) were classified as non-sarcopenic. Phase angle (-0.6±0.2º; p=0.01), reactance (-5.8±2.1 Ohms; p=0.03), SMM (-3.3±0.2 kg; p=0.04), aSMM (-2.1 ±0.3 kg; p=0.03), aSMMI (-0.8±0.2 kg; p=0.03), dominant muscle area (-0.7±0.2 cm²; p=0.04) and dominant Y-axis thickness (-0.4±0.1 cm; p=0.03) were worse in patients with sarcopenia. Mus-cle strength was higher in non-sarcopenic patients (8.5 ± 1.2 kg; p=0.01). Cir-culating BDNF levels were significantly higher in non-sarcopenic patients com-pared to sarcopenic patients (94.7±3.9 ng/mL; p=0.01). Logistic regression analysis indicated a reduced risk of sarcopenia (OR = 0.16, 95% CI = 0.11-0.43; p = 0.03) in patients with higher BDNF levels, after adjusting for BMI, gender, energy intake, and age.
Conclusion: Our study identified an associa-tion between low serum BDNF levels and sarcopenia in patients with disease-related malnutrition (DRM).
期刊介绍:
''Annals of Nutrition and Metabolism'' is a leading international peer-reviewed journal for sharing information on human nutrition, metabolism and related fields, covering the broad and multidisciplinary nature of science in nutrition and metabolism. As the official journal of both the International Union of Nutritional Sciences (IUNS) and the Federation of European Nutrition Societies (FENS), the journal has a high visibility among both researchers and users of research outputs, including policy makers, across Europe and around the world.