Recent Progress in Azobenzene-Based In Vivo Photopharmacology.

IF 10.9 1区 医学 Q1 CHEMISTRY, MEDICINAL
Xin Zhou, Lupei Du, Minyong Li
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引用次数: 0

Abstract

As the most extensively studied photoswitch in photopharmacology, the azobenzene photoswitch has precision instrumental in the photoregulation of physiological processes across various animal models. Currently, it exhibits the greatest clinical potential for photosensitive retinal restoration, capable of inducing long-term therapeutic effects following intravitreal injection, without the need for foreign gene expression or optical fiber implantation. A significant advancement in the application of azobenzene photoswitches is their integration with optical flow control technology, which facilitates the targeting of deep tissues within the mouse cerebral cortex, addressing long-standing challenges related to tissue penetration depth in photopharmacology. With exceptional spatial and temporal resolution, photopharmacology is particularly well-suited for precision medicine, holding substantial potential for further development. Consequently, a comprehensive summary and review of the design strategies of azobenzene photoswitches for In Vivo applications, along with their experimental outcomes, are essential for guiding future advancements in photopharmacology. This review provides an overview of the fundamental properties and design strategies of azobenzene photoswitch molecules. Additionally, we extensively summarize all azobenzene photoswitch molecules successfully applied In Vivo for photopharmacological purposes since 2006, covering species such as Caenorhabditis elegans, Xenopus tadpoles, zebrafish, mice, rats, rabbits, and canines. Finally, we discuss the challenges associated with the In Vivo implementation of azobenzene photoswitch molecules and propose potential solutions.

偶氮苯类体内光药理学研究进展。
偶氮苯光开关是光药理学中研究最广泛的光开关,在各种动物模型的生理过程的光调节中具有精确的工具作用。目前,它在光敏视网膜修复方面表现出最大的临床潜力,能够在玻璃体内注射后诱导长期治疗效果,无需外源基因表达或光纤植入。偶氮苯光开关应用的一个重大进展是其与光流控制技术的集成,这有助于靶向小鼠大脑皮层内的深层组织,解决了光药理学中长期存在的与组织穿透深度相关的挑战。光药理学具有特殊的空间和时间分辨率,特别适合于精准医学,具有进一步发展的巨大潜力。因此,对偶氮苯光开关在体内应用的设计策略及其实验结果进行全面的总结和回顾,对于指导光药理学的未来发展至关重要。本文综述了偶氮苯光开关分子的基本性质和设计策略。此外,我们广泛总结了自2006年以来所有成功应用于体内光药理学目的的偶氮苯光开关分子,涵盖秀丽隐杆线虫、爪蟾蝌蚪、斑马鱼、小鼠、大鼠、兔子和犬等物种。最后,我们讨论了与偶氮苯光开关分子在体内实现相关的挑战,并提出了潜在的解决方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
29.30
自引率
0.00%
发文量
52
审稿时长
2 months
期刊介绍: Medicinal Research Reviews is dedicated to publishing timely and critical reviews, as well as opinion-based articles, covering a broad spectrum of topics related to medicinal research. These contributions are authored by individuals who have made significant advancements in the field. Encompassing a wide range of subjects, suitable topics include, but are not limited to, the underlying pathophysiology of crucial diseases and disease vectors, therapeutic approaches for diverse medical conditions, properties of molecular targets for therapeutic agents, innovative methodologies facilitating therapy discovery, genomics and proteomics, structure-activity correlations of drug series, development of new imaging and diagnostic tools, drug metabolism, drug delivery, and comprehensive examinations of the chemical, pharmacological, pharmacokinetic, pharmacodynamic, and clinical characteristics of significant drugs.
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