Front Cover: Wireframe DNA Origami Capable of Vertex-protruding Transformation (ChemBioChem 10/2025)

Abstract

The cover picture illustrates the reversible transformation of wireframe polyhedral DNA origami, transitioning between an open-form and a closed-form with protruding vertices. Spacer strands between vertices and edges introduce vertex-specific flexibility, enabling designed vertex protrusion. The transformation is driven by DNA hybridization and strand displacement reactions, allowing the structure to switch reversibly between its open and closed states. More details can be found in article 10.1002/cbic.202401071 by Yusuke Sato and co-workers.