Therapeutic Modulation of Demodex Density via Isotretinoin: Insights From a Prospective Dermatological Investigation

IF 2.3 4区医学 Q2 DERMATOLOGY

Journal of Cosmetic Dermatology Pub Date : 2025-05-28 DOI:10.1111/jocd.70249

Ahmed Muayad Jirjees Chakmakchi, Emine Tugba Alatas, Aslan Yurekli, Ceyda Tetik Aydoğdu, Suzan Demir Pektas

{"title":"Therapeutic Modulation of Demodex Density via Isotretinoin: Insights From a Prospective Dermatological Investigation","authors":"Ahmed Muayad Jirjees Chakmakchi, Emine Tugba Alatas, Aslan Yurekli, Ceyda Tetik Aydoğdu, Suzan Demir Pektas","doi":"10.1111/jocd.70249","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Aim</h3>\n \n <p><i>Demodex</i> spp. are ectoparasites that reside in pilosebaceous units, particularly on the face where sebum secretion is prominent. The sebum-reducing effects of isotretinoin play a crucial role in the management of acne vulgaris and rosacea. This study aims to assess the effect of isotretinoin on <i>Demodex</i> density in patients with acne vulgaris and rosacea accompanied by demodicosis. The evaluation includes <i>Demodex</i> mite density, before, during, and after 6 months of isotretinoin treatment.</p>\n </section>\n \n <section>\n \n <h3> Materials Methods</h3>\n \n <p>The study included patients diagnosed with acne vulgaris and rosacea accompanied by demodicosis who were prescribed isotretinoin treatment. Demographic data were collected, and <i>Demodex</i> spp. mites were detected using superficial skin biopsy before treatment initiation. Follow-up samples were obtained at 2 and 6 months. Statistical analysis was performed using SPSS version 23, with a significance level set at <i>p</i> < 0.05.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>A total of 36 patients, 25 with acne and 11 with rosacea, were included in our study. <i>Demodex</i> density was assessed before treatment, at 2 months, and at 6 months. Our findings showed a significant decrease in <i>Demodex</i> density with isotretinoin treatment, especially in relation to the decrease in sebum secretion (<i>p</i> < 0.001).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>This study makes a notable contribution to the existing literature by being the first to assess the impact of isotretinoin treatment on <i>Demodex</i> density. Our results indicate that isotretinoin effectively reduces <i>Demodex</i> density, likely due to a reduction in sebum production. To further explore isotretinoin's effects, future research should involve larger sample sizes and extended follow-up periods. These findings enhance our understanding of isotretinoin's role in managing <i>Demodex</i>-related dermatological conditions.</p>\n </section>\n </div>","PeriodicalId":15546,"journal":{"name":"Journal of Cosmetic Dermatology","volume":"24 6","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jocd.70249","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cosmetic Dermatology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/jocd.70249","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DERMATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Aim

Demodex spp. are ectoparasites that reside in pilosebaceous units, particularly on the face where sebum secretion is prominent. The sebum-reducing effects of isotretinoin play a crucial role in the management of acne vulgaris and rosacea. This study aims to assess the effect of isotretinoin on Demodex density in patients with acne vulgaris and rosacea accompanied by demodicosis. The evaluation includes Demodex mite density, before, during, and after 6 months of isotretinoin treatment.

Materials Methods

The study included patients diagnosed with acne vulgaris and rosacea accompanied by demodicosis who were prescribed isotretinoin treatment. Demographic data were collected, and Demodex spp. mites were detected using superficial skin biopsy before treatment initiation. Follow-up samples were obtained at 2 and 6 months. Statistical analysis was performed using SPSS version 23, with a significance level set at p < 0.05.

Results

A total of 36 patients, 25 with acne and 11 with rosacea, were included in our study. Demodex density was assessed before treatment, at 2 months, and at 6 months. Our findings showed a significant decrease in Demodex density with isotretinoin treatment, especially in relation to the decrease in sebum secretion (p < 0.001).

Conclusion

This study makes a notable contribution to the existing literature by being the first to assess the impact of isotretinoin treatment on Demodex density. Our results indicate that isotretinoin effectively reduces Demodex density, likely due to a reduction in sebum production. To further explore isotretinoin's effects, future research should involve larger sample sizes and extended follow-up periods. These findings enhance our understanding of isotretinoin's role in managing Demodex-related dermatological conditions.

查看原文本刊更多论文

异维甲酸对蠕形螨密度的治疗性调节：来自一项前瞻性皮肤病学调查的见解

目的蠕形螨是一种寄生于皮脂腺单位的体外寄生虫，特别是在皮脂分泌突出的面部。异维甲酸的减脂作用在寻常性痤疮和酒渣鼻的治疗中起着至关重要的作用。本研究旨在评估异维甲酸对寻常型痤疮和酒渣鼻伴蠕形螨病患者蠕形螨密度的影响。评估包括异维甲酸治疗前、期间和6个月后的蠕形螨密度。方法对诊断为寻常性痤疮、酒渣鼻并蠕虫病的患者给予异维甲酸治疗。收集人口统计数据，并在治疗开始前通过皮肤活检检测蠕形螨。随访2个月和6个月。统计学分析采用SPSS version 23，显著性水平设置为p <； 0.05。结果本组共纳入36例患者，其中痤疮25例，酒渣鼻11例。在治疗前、治疗2个月和治疗6个月时评估蠕形螨密度。我们的研究结果显示，异维甲酸治疗显著降低了蠕形螨密度，特别是与皮脂分泌减少有关（p < 0.001）。结论本研究首次评估了异维a酸处理对蠕形螨密度的影响，对现有文献做出了显著贡献。我们的研究结果表明，异维甲酸有效地降低了蠕形螨的密度，可能是由于皮脂产生的减少。为了进一步探索异维甲酸的作用，未来的研究应该包括更大的样本量和更长的随访期。这些发现增强了我们对异维甲酸在管理蠕形螨相关皮肤病中的作用的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Cosmetic Dermatology DERMATOLOGY-

CiteScore

4.30

自引率

13.00%

发文量

818

审稿时长

>12 weeks

期刊介绍： The Journal of Cosmetic Dermatology publishes high quality, peer-reviewed articles on all aspects of cosmetic dermatology with the aim to foster the highest standards of patient care in cosmetic dermatology. Published quarterly, the Journal of Cosmetic Dermatology facilitates continuing professional development and provides a forum for the exchange of scientific research and innovative techniques. The scope of coverage includes, but will not be limited to: healthy skin; skin maintenance; ageing skin; photodamage and photoprotection; rejuvenation; biochemistry, endocrinology and neuroimmunology of healthy skin; imaging; skin measurement; quality of life; skin types; sensitive skin; rosacea and acne; sebum; sweat; fat; phlebology; hair conservation, restoration and removal; nails and nail surgery; pigment; psychological and medicolegal issues; retinoids; cosmetic chemistry; dermopharmacy; cosmeceuticals; toiletries; striae; cellulite; cosmetic dermatological surgery; blepharoplasty; liposuction; surgical complications; botulinum; fillers, peels and dermabrasion; local and tumescent anaesthesia; electrosurgery; lasers, including laser physics, laser research and safety, vascular lasers, pigment lasers, hair removal lasers, tattoo removal lasers, resurfacing lasers, dermal remodelling lasers and laser complications.