Tailoring Lipid Nanoparticle with Ex Situ Incorporated Conjugated Oligoelectrolyte for Enhanced mRNA Delivery Efficiency (Adv. Healthcare Mater. 14/2025)

IF 10 2区医学 Q1 ENGINEERING, BIOMEDICAL

Advanced Healthcare Materials Pub Date : 2025-05-28 DOI:10.1002/adhm.202570087

Wilson Wee Mia Soh, Esteban Finol, Samuel J. W. Chan, Ji-Yu Zhu, Sebastian Sean Jing Kang Liau, Ava Bier, Eng Eong Ooi, Guillermo C. Bazan

引用次数: 0

Abstract

Conjugated Oligoelectrolyte-Enhanced mRNA-Lipid Nanoparticles

In article 2405048, Eng Eong Ooi, Guillermo C. Bazan, and co-workers present a simple ex situ approach to integrate COEs into mRNA-LNPs, enhancing their efficacy. Using just 0.2% COE-S6, a remarkably low amount, one observes significant increases in in cellula transfection and in vivo protein expression. The cover image depicts COEs' fluorescence (green) and enhanced protein expression (red), showcasing COE-mRNA-LNPs' superior performance over unmodified LNPs for therapeutics.

查看原文本刊更多论文

裁剪脂质纳米颗粒与非原位结合的共轭低聚电解质，以提高mRNA的传递效率（Adv. Healthcare Mater. 14/2025）

在文章2405048中，Eng Eong Ooi, Guillermo C. Bazan及其同事提出了一种简单的非原位方法，将COEs整合到mRNA-LNPs中，增强其功效。仅使用0.2%的COE-S6（非常低的量），可以观察到细胞转染和体内蛋白表达的显著增加。封面图描绘了coe的荧光（绿色）和增强的蛋白质表达（红色），表明COE-mRNA-LNPs在治疗方面比未经修饰的LNPs具有更优越的性能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Healthcare Materials 工程技术-生物材料

CiteScore

14.40

自引率

3.00%

发文量

600

审稿时长

1.8 months

期刊介绍： Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.