Yunnan Baiyao-enhanced cellulose nanofiber composite hydrogel wearable patch for transdermal drug delivery and anti-freezing applications

IF 7.7 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

International Journal of Biological Macromolecules Pub Date : 2025-05-26 DOI:10.1016/j.ijbiomac.2025.144684

Xing Gao , Hongchao Zhang , Chufan Yan , Jie Wu , Yutong Wang , Minghao Jiang , Yanan Wang

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引用次数: 0

Abstract

Traditional kinesiology tape has limitations such as poor stretchability, skin irritation, and lack of drug-delivery action. Hydrogels, with their unique physicochemical performance, offer significant potential for developing drug-delivering wearable patches. Yunnan Baiyao (YNBY) and Borneol (BP) are traditional Chinese medicines known for their anti-inflammatory and detoxification effects. In this study, a novel traditional Chinese medicine-loaded composite hydrogel (PPCB-YBx) was prepared by incorporating YNBY and BP into cellulose nanofibers (CNFs) composite biopolymer network. The results showed that the PPCB-YB4 hydrogel exhibited excellent stretchability (~1876 % elongation at break), non-irritating skin adhesion, and sustained drug release behavior (88 % released over 72 h) through a non-Fickian diffusion mechanism. Moreover, it showed good biocompatibility, antibacterial activity, gas permeability, and transdermal properties. The PPCB-YB4 hydrogel also exhibited unique anti-freezing (−27.7 °C) and anti-swelling characteristics (swelling ratio of ~4.5 %) and enhanced water retention, making it suitable for use in extreme environments. These results indicate that the PPCB-YBx hydrogel is a promising drug-releasing wearable patch with potential application prospects in healthcare and sports rehabilitation.

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云南白药增强纤维素纳米纤维复合水凝胶经皮给药抗冻可穿戴贴片

传统的运动机能学胶带有局限性，如拉伸性差，皮肤刺激，缺乏药物传递作用。水凝胶具有独特的物理化学性能，为开发可穿戴贴片提供了巨大的潜力。云南白药（YNBY）和冰片（BP）是传统的中药，以其抗炎和解毒作用而闻名。本研究将YNBY和BP加入到纤维素纳米纤维（CNFs）复合生物聚合物网络中，制备了一种新型的中药负载复合水凝胶（PPCB-YBx）。结果表明，PPCB-YB4水凝胶具有优异的拉伸性能（断裂伸长率~ 1876%），无刺激性皮肤粘附，并通过非菲克扩散机制持续释放药物（72 h内释放88%）。具有良好的生物相容性、抗菌性、透气性和透皮性。PPCB-YB4水凝胶还具有独特的抗冻（- 27.7°C）和抗膨胀特性（溶胀率~ 4.5%），并具有良好的保水性，适合在极端环境中使用。这些结果表明，PPCB-YBx水凝胶是一种很有前景的药物释放可穿戴贴片，在医疗保健和运动康复方面具有潜在的应用前景。

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来源期刊

International Journal of Biological Macromolecules 生物-生化与分子生物学

CiteScore

13.70

自引率

9.80%

发文量

2728

审稿时长

64 days

期刊介绍： The International Journal of Biological Macromolecules is a well-established international journal dedicated to research on the chemical and biological aspects of natural macromolecules. Focusing on proteins, macromolecular carbohydrates, glycoproteins, proteoglycans, lignins, biological poly-acids, and nucleic acids, the journal presents the latest findings in molecular structure, properties, biological activities, interactions, modifications, and functional properties. Papers must offer new and novel insights, encompassing related model systems, structural conformational studies, theoretical developments, and analytical techniques. Each paper is required to primarily focus on at least one named biological macromolecule, reflected in the title, abstract, and text.