Magnetizable flow diverters can magnetically capture and retain endothelial cells to promote healing in rabbit arteries

IF 3 3区医学 Q2 CLINICAL NEUROLOGY

Journal of Neuroradiology Pub Date : 2025-05-24 DOI:10.1016/j.neurad.2025.101353

Alexander A. Oliver , Julien Ognard , Jonathan Cortese , Esref A. Bayraktar , Aleksandra M. Zielonka , David F. Kallmes , Brandon J. Tefft , Ramanathan Kadirvel

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引用次数: 0

Abstract

Flow diverters are effective endovascular devices used to treat intracranial aneurysms by facilitating aneurysm occlusion through endothelial growth across the aneurysm neck. Rapid endothelialization reduces complications such as thrombosis and stenosis. This technical note describes braided, magnetizable flow diverters made from stainless steel alloy 2205 (SS2205) wires designed to magnetically capture autologous blood outgrowth endothelial cells (BOECs) labeled with superparamagnetic iron oxide nanoparticles (SPIONs). Preclinical rabbit artery deployments demonstrated successful magnetic capture and retention of SPION-labeled BOECs, indicating feasibility for accelerated endothelialization. Detailed technical specifications provided in this manuscript ensure precise reproducibility, aiding future studies exploring advanced endothelialization strategies in neuroradiology.

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磁化分流器可以磁性捕获和保留内皮细胞，以促进兔动脉的愈合

血流分流器是一种有效的血管内装置，用于治疗颅内动脉瘤，通过动脉瘤颈部的内皮生长促进动脉瘤闭塞。快速内皮化可减少血栓和狭窄等并发症。本技术说明描述了由不锈钢合金2205 （SS2205）丝制成的编织磁化分流器，设计用于磁性捕获带有超顺磁性氧化铁纳米颗粒（SPIONs）标记的自体血液外生内皮细胞（boec）。兔临床前动脉部署成功地磁捕获和保留了spion标记的boec，表明加速内皮化的可行性。本文提供的详细技术规范确保了精确的可重复性，有助于未来研究探索神经放射学中先进的内皮化策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neuroradiology 医学-核医学

CiteScore

6.10

自引率

5.70%

发文量

142

审稿时长

6-12 weeks

期刊介绍： The Journal of Neuroradiology is a peer-reviewed journal, publishing worldwide clinical and basic research in the field of diagnostic and Interventional neuroradiology, translational and molecular neuroimaging, and artificial intelligence in neuroradiology. The Journal of Neuroradiology considers for publication articles, reviews, technical notes and letters to the editors (correspondence section), provided that the methodology and scientific content are of high quality, and that the results will have substantial clinical impact and/or physiological importance.