Engineering PEG-alginate microcarriers for precision drug Delivery: Optimized design and controlled release

IF 2.4 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Carbohydrate Research Pub Date : 2025-05-20 DOI:10.1016/j.carres.2025.109546

Hossein Madineh , Nadereh Golshan Ebrahimi , Payam Zarrintaj

{"title":"Engineering PEG-alginate microcarriers for precision drug Delivery: Optimized design and controlled release","authors":"Hossein Madineh , Nadereh Golshan Ebrahimi , Payam Zarrintaj","doi":"10.1016/j.carres.2025.109546","DOIUrl":null,"url":null,"abstract":"<div><div>In recent years, polymeric microcarriers have emerged as a targeted approach for controlled drug release. With advantages such as increased drug delivery efficiency, controlled release mechanisms, exceptional stability, and targeted release capabilities, microcarriers have become a focal point of research in drug delivery strategies. In this study, polyethylene glycol (PEG) was first functionalized with sialic acid (SA), and the resulting structure was evaluated using FTIR analysis. The dropwise extrusion method was utilized to form the microcarriers. We employed the central composite design (CCD) method to optimize the fabrication of polymeric microcarriers. Finally optimized microcarriers were prepared with an average particle size of 880 ± 2 <span><math><mrow><mi>μ</mi><mi>m</mi><mtext>.</mtext></mrow></math></span> In the optimal microcarrier, the amounts of loaded drug and its efficiency were 90 % and 91 %, respectively. The results indicated the release of curcumin in the prepared system compared to free curcumin was controlled and long-lasting. The utilization of polymeric microcarriers as a targeted approach for controlled drug release holds great promise in revolutionizing the field of drug delivery. This research not only enhances our understanding of the potential applications of microcarriers but also opens up new horizons for advancing controlled drug release strategies, ultimately leading to more effective and personalized treatments for various diseases.</div></div>","PeriodicalId":9415,"journal":{"name":"Carbohydrate Research","volume":"554 ","pages":"Article 109546"},"PeriodicalIF":2.4000,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Carbohydrate Research","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0008621525001727","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

In recent years, polymeric microcarriers have emerged as a targeted approach for controlled drug release. With advantages such as increased drug delivery efficiency, controlled release mechanisms, exceptional stability, and targeted release capabilities, microcarriers have become a focal point of research in drug delivery strategies. In this study, polyethylene glycol (PEG) was first functionalized with sialic acid (SA), and the resulting structure was evaluated using FTIR analysis. The dropwise extrusion method was utilized to form the microcarriers. We employed the central composite design (CCD) method to optimize the fabrication of polymeric microcarriers. Finally optimized microcarriers were prepared with an average particle size of 880 ± 2

μ m .

In the optimal microcarrier, the amounts of loaded drug and its efficiency were 90 % and 91 %, respectively. The results indicated the release of curcumin in the prepared system compared to free curcumin was controlled and long-lasting. The utilization of polymeric microcarriers as a targeted approach for controlled drug release holds great promise in revolutionizing the field of drug delivery. This research not only enhances our understanding of the potential applications of microcarriers but also opens up new horizons for advancing controlled drug release strategies, ultimately leading to more effective and personalized treatments for various diseases.

查看原文本刊更多论文

工程聚乙二醇海藻酸盐微载体的精确给药：优化设计和控释

近年来，聚合物微载体已成为一种药物控制释放的靶向途径。微载体具有提高药物传递效率、控制释放机制、优异的稳定性和靶向释放能力等优点，已成为药物传递策略研究的热点。在这项研究中，聚乙二醇（PEG）首先与唾液酸（SA）功能化，并通过FTIR分析对所得结构进行了评价。采用滴挤出法制备微载体。采用中心复合设计（CCD）方法对聚合物微载体的制备进行了优化。优化后的微载体平均粒径为880±2 μm。在最佳微载体中，载药量为90%，载药率为91%。结果表明，与游离姜黄素相比，所制备体系中姜黄素的释放是可控且持久的。利用聚合物微载体作为一种靶向药物控制释放的方法，在彻底改变药物递送领域具有很大的前景。本研究不仅提高了我们对微载体潜在应用的认识，而且为推进药物控释策略开辟了新的视野，最终实现对各种疾病更有效和个性化的治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Carbohydrate Research 化学-生化与分子生物学

CiteScore

5.00

自引率

3.20%

发文量

183

审稿时长

3.6 weeks

期刊介绍： Carbohydrate Research publishes reports of original research in the following areas of carbohydrate science: action of enzymes, analytical chemistry, biochemistry (biosynthesis, degradation, structural and functional biochemistry, conformation, molecular recognition, enzyme mechanisms, carbohydrate-processing enzymes, including glycosidases and glycosyltransferases), chemical synthesis, isolation of natural products, physicochemical studies, reactions and their mechanisms, the study of structures and stereochemistry, and technological aspects. Papers on polysaccharides should have a "molecular" component; that is a paper on new or modified polysaccharides should include structural information and characterization in addition to the usual studies of rheological properties and the like. A paper on a new, naturally occurring polysaccharide should include structural information, defining monosaccharide components and linkage sequence. Papers devoted wholly or partly to X-ray crystallographic studies, or to computational aspects (molecular mechanics or molecular orbital calculations, simulations via molecular dynamics), will be considered if they meet certain criteria. For computational papers the requirements are that the methods used be specified in sufficient detail to permit replication of the results, and that the conclusions be shown to have relevance to experimental observations - the authors'' own data or data from the literature. Specific directions for the presentation of X-ray data are given below under Results and "discussion".