Necroptosis and its role in the pathogenesis and treatment of temporomandibular joint osteoarthritis: A narrative review

IF 2.1 4区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Archives of oral biology Pub Date : 2025-05-22 DOI:10.1016/j.archoralbio.2025.106300

Miaomiao Zhao , Luyao Song , Zhichao Liu, Yuting Li, Yingnan Wang

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Abstract

Objective

This review aimed to explore the role of necroptosis in the pathogenesis and treatment of temporomandibular joint osteoarthritisjoints. We sought to elucidate the mechanisms by which necroptosis contributes to arthritis development and identify potential therapeutic targets within the necroptosis pathway.

Design

An electronic literature search was conducted in PubMed, Scopus, EBSCO, ProQuest, ScienceDirect, and Springer for studies on necroptosis, arthritis, and temporomandibular joint osteoarthritis published between 2004 and 2024.

Results

Necroptosis, a programmed cell death pathway characterized by the activation of receptor-interacting protein kinase 1/3, leads to cell membrane rupture and the release of damage-associated molecular patterns, which are instrumental in promoting inflammation. This review highlights the involvement of necroptosis in the progression of multiple types of arthritis, especially temporomandibular joint osteoarthritis. These findings highlight the potential of necroptosis inhibitors as therapeutic agents, with several small-molecule inhibitors demonstrating efficacy in preclinical models of arthritis.

Conclusions

Necroptosis is a significant factor in the pathogenesis of arthritis, particularly temporomandibular joint osteoarthritis, and represents a promising therapeutic target. Targeting the necroptosis pathway may offer a novel approach for managing joint damage and osteochondral inflammation. Further research is necessary to fully understand the mechanisms of necroptosis in temporomandibular joint osteoarthritis and to develop targeted therapies for clinical application.

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坏死性上睑下垂及其在颞下颌关节骨性关节炎发病机制和治疗中的作用：综述

目的探讨坏死性上睑下垂在颞下颌关节骨性关节炎发病机制及治疗中的作用。我们试图阐明坏死性下垂促进关节炎发展的机制，并在坏死性下垂途径中确定潜在的治疗靶点。设计在PubMed、Scopus、EBSCO、ProQuest、ScienceDirect和施普林格中进行电子文献检索，检索2004年至2024年间发表的关于坏死性下垂、关节炎和颞下颌关节骨关节炎的研究。结果坏死坏死是一种程序性细胞死亡途径，其特征是受体相互作用蛋白激酶1/3的激活，导致细胞膜破裂和损伤相关分子模式的释放，有助于促进炎症反应。这篇综述强调了坏死性上睑下垂在多种类型关节炎，特别是颞下颌关节骨关节炎进展中的作用。这些发现突出了坏死性下垂抑制剂作为治疗药物的潜力，几种小分子抑制剂在关节炎的临床前模型中显示出疗效。结论坏死性上睑下垂是关节炎尤其是颞下颌关节骨性关节炎发病的重要因素，是一个有前景的治疗靶点。靶向坏死下垂途径可能为治疗关节损伤和骨软骨炎症提供一种新的途径。为了充分了解颞下颌关节骨性关节炎坏死性上睑下垂的发病机制，并为临床应用开发有针对性的治疗方法，还需要进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of oral biology 医学-牙科与口腔外科

CiteScore

5.10

自引率

3.30%

发文量

177

审稿时长

26 days

期刊介绍： Archives of Oral Biology is an international journal which aims to publish papers of the highest scientific quality in the oral and craniofacial sciences. The journal is particularly interested in research which advances knowledge in the mechanisms of craniofacial development and disease, including: Cell and molecular biology Molecular genetics Immunology Pathogenesis Cellular microbiology Embryology Syndromology Forensic dentistry