An AIE-activated fluorescent sensor for one-step concurrent detection and bioimaging of perfluorooctanoic acid and perfluorooctane sulfonate in vitro and in vivo

IF 12.2 1区环境科学与生态学 Q1 ENGINEERING, ENVIRONMENTAL

Journal of Hazardous Materials Pub Date : 2025-05-27 DOI:10.1016/j.jhazmat.2025.138765

Penglai Yao, Jiale Ou, Dede Zhao, Shuping Zhou, Qi Wang, Yan Feng, Man Chen, Xiangming Meng

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引用次数: 0

Abstract

Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) have emerged as global concerns due to their environmental persistence and associated toxicity. Therefore, accurate detection of PFOA/PFOS in water samples and biological systems is of great importance. In this study, we have designed and synthesized a novel fluorescent sensor ES based on tetraphenyl derivatives for one-step concurrent detection of PFOA and PFOS. The sensor exhibits a rapid response, high selectivity, high sensitivity, and a large Stokes shift. Both experimental and theoretical calculations indicate that PFOA/PFOS induced aggregation of the sensor ES through electrostatic and hydrophobic interactions, thereby activating its aggregation-induced emission (AIE) effect. The sensor ES can be further utilized for the detection of PFOA/PFOS in real water samples, and a portable smartphone-based analyzer system has been developed for rapid on-site detection. In addition, ES demonstrates low biotoxicity, which enhances its applicability in detecting PFOA/PFOS in living cells, zebrafish, and mice. This suggests the potential of ES for biological applications in the real-time monitoring PFOA/PFOS.

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一种体外和体内全氟辛酸和全氟辛烷磺酸一步同步检测和生物成像的aie激活荧光传感器

全氟辛酸（PFOA）和全氟辛烷磺酸（PFOS）由于其环境持久性和相关毒性已成为全球关注的问题。因此，准确检测水样和生物系统中的PFOA/PFOS具有重要意义。在这项研究中，我们设计并合成了一种基于四苯基衍生物的新型荧光传感器ES，用于一步同时检测PFOA和PFOS。该传感器具有响应快、选择性高、灵敏度高、斯托克斯位移大等特点。实验和理论计算均表明PFOA/PFOS通过静电和疏水相互作用诱导传感器ES聚集，从而激活其聚集诱导发射（AIE）效应。传感器ES可进一步用于实际水样中PFOA/PFOS的检测，并开发了一种基于智能手机的便携式分析仪系统，用于现场快速检测。此外，ES具有较低的生物毒性，这增强了其在活细胞、斑马鱼和小鼠中检测PFOA/PFOS的适用性。这表明ES在实时监测全氟辛烷磺酸/全氟辛烷磺酸方面具有生物学应用潜力。

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来源期刊

Journal of Hazardous Materials 工程技术-工程：环境

CiteScore

25.40

自引率

5.90%

发文量

3059

审稿时长

58 days

期刊介绍： The Journal of Hazardous Materials serves as a global platform for promoting cutting-edge research in the field of Environmental Science and Engineering. Our publication features a wide range of articles, including full-length research papers, review articles, and perspectives, with the aim of enhancing our understanding of the dangers and risks associated with various materials concerning public health and the environment. It is important to note that the term "environmental contaminants" refers specifically to substances that pose hazardous effects through contamination, while excluding those that do not have such impacts on the environment or human health. Moreover, we emphasize the distinction between wastes and hazardous materials in order to provide further clarity on the scope of the journal. We have a keen interest in exploring specific compounds and microbial agents that have adverse effects on the environment.