Intelligent anatomic design of porous radial head prosthesis and microscopic-macro biomechanical finite element analysis in the long-term after replacement surgery

IF 2 3区医学 Q2 ANATOMY & MORPHOLOGY

Annals of Anatomy-Anatomischer Anzeiger Pub Date : 2025-05-22 DOI:10.1016/j.aanat.2025.152678

Hao Ye , Xi Li , Chuxuan Zhi , Tingyang Xing , Junhan Chai , Jiawei Lou , Xiaoli Zhu , Yimin Zhao , Huan Guo , Shuming Huang , Fuqian Shi , Xianjing Kong , Shizhen Zhong , Yingze Zhang , Lijun Wu

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Abstract

Background

The microporous structure of porous titanium alloy may affect osteoblast differentiation and reduce effective elastic modulus (EEM) of the prostheses. Therefore, the biomechanics-based anatomic design of porous radial head prosthesis (PRHP) may help promote bone healing and reduce postoperative complications.

Methods

A microscopic-macro virtual testing platform (VTP) was built to design cells with excellent mechanical properties, further, to construct the PRHP. An intelligent anatomic platform of healthy human elbow-forearms was developed to construct finite element (FE) models of solid radial head prosthesis (SRHP) and PRHP replacement for Mason type III fractures. Axial and valgus loads were applied for surgical model validation and microscopic-macro biomechanical analysis.

Results

The order of ultimate compressive load (UCL) and yield strength (YS) of five types of cells is NEWTET>KAGOME>NEWPYRAMID>TET>PYRAMID. Under the same porosity conditions, UCL and YS of the double and four-layer lattice structures of NEWTET decreased by 62.39 %, 69.46 % and 61.70 %, 70.21 % compared to the single-layer, respectively. The EEM of NEWTET-based PRHP is 17.66 % of that of SRHP. Compared with the SRHP replacement, PRHP replacement reduced the humeral cartilage stress by 18.96 %–19.51 %.

Conclusions

NEWTET cell has better microscopic mechanical properties and bone-growth adaptability. The EEM of NEWTET-based PRHP closely resembles cortical bone. Compared with SRHP replacement, microscopic-macro biomechanical performance in long-term after PRHP replacement is closer to that of a normal elbow joint. The microscopic-macro VTP and human intelligent anatomic elbow-forearm FE analysis systems provide efficient, accurate, and smart tools for the design of porous prostheses in joint replacement surgery.

查看原文本刊更多论文

多孔桡骨头假体智能解剖设计及置换术后长期显微-宏观生物力学有限元分析。

背景：多孔钛合金的微孔结构可能影响成骨细胞分化，降低假体的有效弹性模量（EEM）。因此，基于生物力学的多孔桡骨头假体（PRHP）的解剖设计可能有助于促进骨愈合和减少术后并发症。方法：建立微观-宏观虚拟测试平台，设计具有优良力学性能的细胞，构建PRHP。建立健康人体肘部-前臂智能解剖平台，构建实心桡骨头假体（SRHP）和PRHP置换Mason III型骨折的有限元模型。轴向和外翻载荷应用于手术模型验证和微观-宏观生物力学分析。结果：5种细胞的极限抗压载荷（UCL）和屈服强度（YS）大小依次为：NEWTET>KAGOME>NEWPYRAMID>TET>PYRAMID。在相同孔隙率条件下，NEWTET双层和四层晶格结构的UCL和YS分别比单层降低了62.39%、69.46%和61.70%、70.21%。基于newtet的PRHP的EEM为SRHP的17.66%。与SRHP置换术相比，PRHP置换术使肱骨软骨应力降低18.96% ~ 19.51%。结论：NEWTET细胞具有较好的显微力学性能和骨生长适应性。newtet基PRHP的EEM与皮质骨非常相似。与SRHP置换术相比，PRHP置换术后的长期微观-宏观生物力学性能更接近正常肘关节。显微-宏观VTP和人体智能解剖肘关节-前臂有限元分析系统为关节置换术中多孔假体的设计提供了高效、准确和智能的工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Anatomy-Anatomischer Anzeiger 医学-解剖学与形态学

CiteScore

4.40

自引率

22.70%

发文量

137

审稿时长

33 days

期刊介绍： Annals of Anatomy publish peer reviewed original articles as well as brief review articles. The journal is open to original papers covering a link between anatomy and areas such as •molecular biology, •cell biology •reproductive biology •immunobiology •developmental biology, neurobiology •embryology as well as •neuroanatomy •neuroimmunology •clinical anatomy •comparative anatomy •modern imaging techniques •evolution, and especially also •aging