{"title":"Biofilms and Antimicrobial Resistance in Healthcare: Evaluating Chlorine Dioxide as a Candidate to Protect Patient Safety.","authors":"P Norville, S Dangleben, S Hardy","doi":"10.1016/j.jhin.2025.04.034","DOIUrl":null,"url":null,"abstract":"<p><p>Healthcare-associated infections (HAIs) caused by the transmission of multi drug resistant organisms (MDROs) from contaminated surfaces are a major challenge for healthcare organisations. The presence of biofilm on surfaces makes effective environmental decontamination difficult to achieve and exacerbates antimicrobial resistance (AMR). In this study the performance of various chlorine dioxide-based disinfectants against a panel of MDROs, and biofilms formed by Pseudomonas aeruginosa and Staphylococcus aureus, was evaluated. All chlorine dioxide-based disinfectants tested demonstrated sufficient activity against MDROs meeting the relevant test standards and exhibited similar log reductions against organisms within the biofilm model. Sufficient log reductions when tested to the appropriate test standards in realistic contact times against planktonic MDROs, and comparable reductions against biofilms suggest chlorine dioxide is an attractive candidate for environmental decontamination strategies.</p>","PeriodicalId":54806,"journal":{"name":"Journal of Hospital Infection","volume":" ","pages":""},"PeriodicalIF":3.9000,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Hospital Infection","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jhin.2025.04.034","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0
Abstract
Healthcare-associated infections (HAIs) caused by the transmission of multi drug resistant organisms (MDROs) from contaminated surfaces are a major challenge for healthcare organisations. The presence of biofilm on surfaces makes effective environmental decontamination difficult to achieve and exacerbates antimicrobial resistance (AMR). In this study the performance of various chlorine dioxide-based disinfectants against a panel of MDROs, and biofilms formed by Pseudomonas aeruginosa and Staphylococcus aureus, was evaluated. All chlorine dioxide-based disinfectants tested demonstrated sufficient activity against MDROs meeting the relevant test standards and exhibited similar log reductions against organisms within the biofilm model. Sufficient log reductions when tested to the appropriate test standards in realistic contact times against planktonic MDROs, and comparable reductions against biofilms suggest chlorine dioxide is an attractive candidate for environmental decontamination strategies.
期刊介绍：
The Journal of Hospital Infection is the editorially independent scientific publication of the Healthcare Infection Society. The aim of the Journal is to publish high quality research and information relating to infection prevention and control that is relevant to an international audience.
The Journal welcomes submissions that relate to all aspects of infection prevention and control in healthcare settings. This includes submissions that:
provide new insight into the epidemiology, surveillance, or prevention and control of healthcare-associated infections and antimicrobial resistance in healthcare settings;
provide new insight into cleaning, disinfection and decontamination;
provide new insight into the design of healthcare premises;
describe novel aspects of outbreaks of infection;
throw light on techniques for effective antimicrobial stewardship;
describe novel techniques (laboratory-based or point of care) for the detection of infection or antimicrobial resistance in the healthcare setting, particularly if these can be used to facilitate infection prevention and control;
improve understanding of the motivations of safe healthcare behaviour, or describe techniques for achieving behavioural and cultural change;
improve understanding of the use of IT systems in infection surveillance and prevention and control.
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