Wildfire-Related Air Pollution and Infectious Diseases: Systematic Review and Meta-Analysis.

Abstract

Amid the global rise in wildfire events, the health impacts of wildfire-related air pollution are increasingly scrutinized. While numerous reviews have examined the link between air pollution and infectious diseases, reviews specifically focusing on wildfire-related air pollution and infectious diseases remain scarce. To address this gap, we conducted a comprehensive search in MEDLINE, EMBASE, Scopus and Web of Science databases up to December 31, 2023, using PRISMA (Preferred Reporting Items for Systematic Reviews & Meta-Analyses) guidelines. Search terms included synonyms of wildfire and infectious diseases. Peer-reviewed epidemiological studies that reported any association or trend between wildfire air pollution and infectious diseases were selected against eligibility criteria. Risk of bias and quality of included studies were assessed using modified risk of bias and quality assessment tools. Our review included 30 studies, predominantly from developed countries including the United States (USA), Australia, and Canada. Most focused on respiratory infectious diseases (n = 29), including 9 specifically on the coronavirus disease 2019 (COVID-19). The majority examined short-term wildfire air pollution (n = 27) (exposure of one month or less). Twenty-three studies reported effect estimates for the meta-analysis. We found that a 10 μg/m³ increase in short-term wildfire PM_2.5 (particulate matter with a diameter of 2.5 micrometer of less) exposure was associated with a 15% increase in COVID-19 infections (relative risk [RR] = 1.15; 95% confidence interval [CI]: 1.09-1.21; heterogeneity (I ²): 83%), a 3% increase in respiratory diseases (RR = 1.03; 95% CI: 1.01-1.05; I ²: 0%) and a 3% increase in acute upper respiratory infection combined with acute bronchitis (RR = 1.03; 95% CI: 1.02-1.05; I ²: 62%). Medium-term exposure (more than a month but less than a year) to wildfire smoke was associated with 20% rising hospitalization for systemic fungal infections like coccidioidomycosis (95% CI: 5-38%). The current research exclusively examines respiratory infections in developed countries. Future high-quality primary studies should prioritize understanding the impact of wildfire-related air pollution on various infectious diseases.