Sensory neuropathy and associated factors among patients living with human immuno-deficiency virus in Africa: a systematic review and meta-analysis.

IF 4 3区医学 Q2 VIROLOGY

Virology Journal Pub Date : 2025-05-24 DOI:10.1186/s12985-025-02789-5

Worku Chekol Tassew, Ashebir Mamay Gebiru, Mihret Getnet, Berihun Agegn Mengistie, Desalegn Anmut Bitew, Amare Belete Getahun, Desale Bihonegn Asmamaw, Mikias Mered Tilahun, Mihret Melese, Nebebe Demis Baykemagn, Yimer Mamaye, Yosef Belay Bizuneh, Habtu Kifle Negash

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引用次数: 0

Abstract

Introduction: Despite high prevalence of sensory neuropathy among individuals living with HIV, there is no comprehensive information regarding variables that determine sensory neuropathy onset among the patients who attended health care facilities. In conditions where there is a high number of patients with sensory neuropathy, clinicians confront challenges in managing the problem, and increase the burden of health care expenditures. This study aimed to determine the prevalence of peripheral neuropathy and associated factors among people living with HIV in Africa.

Methods: To ensure the transparency, accuracy, and thoroughness of this systematic review and meta-analysis, we adhered to the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Systematic electronic searches were conducted across several databases, including African Journal Online, Google Scholar, PubMed, Scopus, and the Wiley Online Library. Articles found during the searching were imported into EndNote software version X7, where duplicates were removed. The extracted data were then imported to Microsoft Excel and analyzed using STATA version 11 for analysis. The Q statistic and I² test were employed to evaluate heterogeneity between studies.

Results: The initial search identified 1,821 articles, which were organized using citation management software. The current meta-analysis found that 36.46% (95% CI: 26.48-46.44, I² = 87.1%) patients living with HIV/AIDS experience peripheral sensory neuropathy. Factors associated with peripheral neuropathy included being older than 40 years (OR = 2.40; 95% CI: 01.24, 4.64), having viral load greater than 1,000 copies (OR = 2.46; 95% CI: 1.03, 5.88) and having a CD4 count below 200 cells (OR = 4.30; 95% CI: 1.24, 14.98).

Conclusion: This study found that peripheral sensory neuropathy is highly prevalent among HIV-infected individuals in Africa. Advanced age, elevated viral load, and low CD4 count were identified as independent predictors of HIV-related peripheral neuropathy. It is recommended that simple, established neurological screening methods be regularly used to identify early signs of HIV-SN or individuals at risk, across all patients.

查看原文本刊更多论文

非洲人类免疫缺陷病毒感染者的感觉神经病变及其相关因素：一项系统回顾和荟萃分析

导论：尽管艾滋病毒感染者中感觉神经病变的患病率很高，但没有关于确定就诊于卫生保健机构的患者中感觉神经病变发病的变量的综合信息。在有大量患者感觉神经病变的情况下，临床医生面临着管理问题的挑战，并增加了卫生保健支出的负担。本研究旨在确定非洲艾滋病毒感染者中周围神经病变的患病率及其相关因素。方法：为了确保本系统评价和荟萃分析的透明度、准确性和彻彻性，我们遵循了系统评价和荟萃分析首选报告项目声明中概述的指南。在几个数据库中进行了系统的电子搜索，包括非洲期刊在线，谷歌学者，PubMed， Scopus和Wiley在线图书馆。在搜索过程中发现的文章被导入到EndNote软件版本X7中，其中副本被删除。然后将提取的数据导入Microsoft Excel，使用STATA version 11进行分析。采用Q统计量和I2检验评价研究间的异质性。结果：最初的搜索确定了1821篇文章，这些文章是用引文管理软件组织的。目前的荟萃分析发现，36.46% （95% CI: 26.48-46.44, I2 = 87.1%）的HIV/AIDS患者出现周围感觉神经病变。与周围神经病变相关的因素包括：年龄大于40岁(OR = 2.40；95% CI: 01.24, 4.64)，病毒载量大于1000拷贝(OR = 2.46；95% CI: 1.03, 5.88)， CD4计数低于200个细胞(OR = 4.30；95% ci: 1.24, 14.98)。结论：本研究发现周围感觉神经病变在非洲hiv感染者中非常普遍。高龄、病毒载量升高和低CD4计数被确定为hiv相关周围神经病变的独立预测因子。建议在所有患者中定期使用简单的、已建立的神经系统筛查方法来识别HIV-SN的早期体征或高危个体。

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来源期刊

Virology Journal 医学-病毒学

CiteScore

7.40

自引率

2.10%

发文量

186

审稿时长

1 months

期刊介绍： Virology Journal is an open access, peer reviewed journal that considers articles on all aspects of virology, including research on the viruses of animals, plants and microbes. The journal welcomes basic research as well as pre-clinical and clinical studies of novel diagnostic tools, vaccines and anti-viral therapies. The Editorial policy of Virology Journal is to publish all research which is assessed by peer reviewers to be a coherent and sound addition to the scientific literature, and puts less emphasis on interest levels or perceived impact.