"Schizophrenia, Consciousness, and the Self" Twenty Years Later: Revisiting the Ipseity-Disturbance Model and the Developmental Nature of Self-Disorder in the Schizophrenia Spectrum.

IF 5.3 1区 医学 Q1 PSYCHIATRY
Andrea Raballo, Mads Gram Henriksen, Michele Poletti, Josef Parnas
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引用次数: 0

Abstract

Self-disorders (SD) designate a pattern of non-psychotic anomalous self-experiences, which specifically aggregate in clinical and subclinical forms of schizophrenia spectrum disorders (SSD), including familial high-risk configurations. SD have been corroborated as a valuable, quantitatively tractable, trait phenotype for indexing genetic liability to SSD, and, as a risk phenotype, they offer critical insights into the nature of these complex conditions which precede and shape the development of more overt clinical manifestations (including schizotypal features and positive, negative, and disorganized symptoms). In the last three decades, the concept of self-disorders has evolved from early clinical observations to a well-defined research domain, offering a nuanced understanding of schizophrenia spectrum vulnerabilities and holding promise for improving diagnostic accuracy, enhancing prognostic assessments, offering novel targets for intervention, and advancing our understanding of the schizophrenia spectrum.

“精神分裂症,意识和自我”二十年后:重新审视精神分裂症谱系中易激-障碍模型和自我障碍的发展本质。
自我障碍(SD)是指一种非精神病性的异常自我体验模式,特别是在精神分裂症谱系障碍(SSD)的临床和亚临床形式中聚集,包括家族性高风险配置。SD已被证实是一种有价值的、可定量处理的、用于索引SSD遗传倾向性的特征表型,并且,作为一种风险表型,它们提供了对这些复杂条件的本质的关键见解,这些条件先于并塑造了更明显的临床表现(包括分裂型特征和阳性、阴性和无序症状)的发展。在过去的三十年中,自我障碍的概念已经从早期的临床观察发展到一个定义明确的研究领域,提供了对精神分裂症谱系脆弱性的细致理解,并有望提高诊断准确性,加强预后评估,提供新的干预目标,并推进我们对精神分裂症谱系的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Schizophrenia Bulletin
Schizophrenia Bulletin 医学-精神病学
CiteScore
11.40
自引率
6.10%
发文量
163
审稿时长
4-8 weeks
期刊介绍: Schizophrenia Bulletin seeks to review recent developments and empirically based hypotheses regarding the etiology and treatment of schizophrenia. We view the field as broad and deep, and will publish new knowledge ranging from the molecular basis to social and cultural factors. We will give new emphasis to translational reports which simultaneously highlight basic neurobiological mechanisms and clinical manifestations. Some of the Bulletin content is invited as special features or manuscripts organized as a theme by special guest editors. Most pages of the Bulletin are devoted to unsolicited manuscripts of high quality that report original data or where we can provide a special venue for a major study or workshop report. Supplement issues are sometimes provided for manuscripts reporting from a recent conference.
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