Recommendations for radiotherapy quality assurance in clinical trials.

IF 4.9 1区医学 Q1 ONCOLOGY

Radiotherapy and Oncology Pub Date : 2025-05-22 DOI:10.1016/j.radonc.2025.110950

Camilla Panduro Nielsen, Eva Samsøe, Birgitte Vrou Offersen, Ebbe Laugaard Lorenzen, Gitte Persson, Hanna Rahbek Mortensen, Henrik Dahl Nissen, Ivan Richter Vogelius, Jesper Folsted Kallehauge, Ludvig Paul Muren, Mads Brincker, Mette van Overeem Felter, Rikke Hedegaard Dahlrot, Steffen Bjerre Hokland, Tine Schytte, Birgitte Mayland Havelund, Britta Weber, Ditte Sloth Møller, Eva Serup-Hansen, Kenneth Jensen, Kirsten Legård Jakobsen, Mirjana Josipovic, Simon Long Krogh, Slávka Lukacova, Lone Hoffmann, Christian Rønn Hansen

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引用次数: 0

Abstract

Robust quality assurance (QA) of clinical trials in radiotherapy (RT) is paramount for minimising uncertainties in treatment delivery, thereby strengthening the statistical power of the study and increasing the likelihood of accurately answering the research question. As RT techniques evolve and become more complex, establishing an appropriate QA program for a specific clinical trial becomes increasingly challenging, highlighting the importance of clear and standardised recommendations. This study provide such recommendations for Principal Investigators (PIs) to consider when planning and conducting RT Quality Assurance (RTQA) for clinical trials. They arise from experiences with RTQA in the clinical trials conducted in the Danish Multidisciplinary Cancer Groups (DMCGs). The recommendations include a checklist to guide PIs in developing an effective RTQA program.

查看原文本刊更多论文

临床试验中放疗质量保证的建议。

放射治疗（RT）临床试验的可靠质量保证（QA）对于最大限度地减少治疗交付的不确定性至关重要，从而加强研究的统计效力并增加准确回答研究问题的可能性。随着RT技术的发展和变得越来越复杂，为特定的临床试验建立适当的QA计划变得越来越具有挑战性，这突出了明确和标准化建议的重要性。本研究为主要研究者（pi）在规划和实施临床试验的RT质量保证（RTQA）时提供了这样的建议。它们来自丹麦多学科癌症小组（dmcg）进行的临床试验中RTQA的经验。建议包括一份清单，以指导项目负责人制定有效的RTQA计划。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Radiotherapy and Oncology 医学-核医学

CiteScore

10.30

自引率

10.50%

发文量

2445

审稿时长

45 days

期刊介绍： Radiotherapy and Oncology publishes papers describing original research as well as review articles. It covers areas of interest relating to radiation oncology. This includes: clinical radiotherapy, combined modality treatment, translational studies, epidemiological outcomes, imaging, dosimetry, and radiation therapy planning, experimental work in radiobiology, chemobiology, hyperthermia and tumour biology, as well as data science in radiation oncology and physics aspects relevant to oncology.Papers on more general aspects of interest to the radiation oncologist including chemotherapy, surgery and immunology are also published.