Association between Phthalate exposure and Reproductive Health in Patients Undergoing Assisted Reproductive Treatment: A Systematic Review and Meta-Analysis.

IF 3.3 4区医学 Q2 REPRODUCTIVE BIOLOGY

Reproductive toxicology Pub Date : 2025-05-23 DOI:10.1016/j.reprotox.2025.108948

Guangmei Xie, Yongjia Zhou, Li Wang, Yan Wang, Haijing Zeng, Jialing Wang, Xinyan Li

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引用次数: 0

Abstract

This systematic review and meta-analysis synthesizes current literature examining the relationship between phthalate exposure and reproductive health in patients undergoing assisted reproductive treatment (ART). We conducted a comprehensive search across multiple databases, including PubMed, Web of Science, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), China Science and Technology Journal Database (VIP), and Wanfang databases. From 16 relevant publications identified, five studies were included in the systematic review and 11 in the meta-analysis. Our findings indicate that most of the 18 phthalate metabolites analyzed demonstrated negative associations with reproductive health outcomes in ART patients. High molecular weight phthalates, particularly mono (2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), were most frequently linked to adverse outcomes, followed by metabolites such as mono-isobutyl phthalate (MiBP), mono-benzyl phthalate (MBzP). Both high and low molecular weight phthalates, including monoethyl phthalate (MEP) and MiBP, were correlated with negative reproductive outcomes. However, no significant associations were observed between mono-2-ethyl-5-hydroxyhexyl terephthalate (MEHHTP) or mono-3-hydroxybutyl phthalate (MHBP) and reproductive health parameters. Our analysis suggests that phthalate exposure may adversely affect fertility, hormone levels, and gamete quality, while also being associated with pregnancy complications and oxidative stress. These findings underscore the need for further large-scale studies to confirm these relationships and their clinical implications.

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邻苯二甲酸盐暴露与辅助生殖治疗患者生殖健康的关系：一项系统综述和荟萃分析。

本系统综述和荟萃分析综合了目前研究邻苯二甲酸盐暴露与辅助生殖治疗（ART）患者生殖健康之间关系的文献。我们在PubMed、Web of Science、Embase、Cochrane Library、中国知网（CNKI）、中国生物医学文献数据库（CBM）、中国科技期刊数据库（VIP）、万方数据库等多个数据库进行了全面检索。从16篇相关出版物中，5篇研究纳入系统评价，11篇纳入荟萃分析。我们的研究结果表明，所分析的18种邻苯二甲酸酯代谢物中的大多数与抗逆转录病毒治疗患者的生殖健康结果呈负相关。高分子量邻苯二甲酸酯，特别是邻苯二甲酸单（2-乙基-5-羟基己基）酯（MEHHP），最常与不良后果相关，其次是代谢物，如邻苯二甲酸单异丁酯（MiBP）、邻苯二甲酸单苄基（MBzP）。高分子量和低分子量邻苯二甲酸酯，包括邻苯二甲酸一乙酯（MEP）和MiBP，都与阴性生殖结果相关。然而，邻苯二甲酸单-2-乙基-5-羟基己酯（MEHHTP）或邻苯二甲酸单-3-羟基丁酯（MHBP）与生殖健康参数之间没有显著关联。我们的分析表明，邻苯二甲酸盐暴露可能对生育能力、激素水平和配子质量产生不利影响，同时还与妊娠并发症和氧化应激有关。这些发现强调需要进一步的大规模研究来证实这些关系及其临床意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reproductive toxicology 生物-毒理学

CiteScore

6.50

自引率

3.00%

发文量

131

审稿时长

45 days

期刊介绍： Drawing from a large number of disciplines, Reproductive Toxicology publishes timely, original research on the influence of chemical and physical agents on reproduction. Written by and for obstetricians, pediatricians, embryologists, teratologists, geneticists, toxicologists, andrologists, and others interested in detecting potential reproductive hazards, the journal is a forum for communication among researchers and practitioners. Articles focus on the application of in vitro, animal and clinical research to the practice of clinical medicine. All aspects of reproduction are within the scope of Reproductive Toxicology, including the formation and maturation of male and female gametes, sexual function, the events surrounding the fusion of gametes and the development of the fertilized ovum, nourishment and transport of the conceptus within the genital tract, implantation, embryogenesis, intrauterine growth, placentation and placental function, parturition, lactation and neonatal survival. Adverse reproductive effects in males will be considered as significant as adverse effects occurring in females. To provide a balanced presentation of approaches, equal emphasis will be given to clinical and animal or in vitro work. Typical end points that will be studied by contributors include infertility, sexual dysfunction, spontaneous abortion, malformations, abnormal histogenesis, stillbirth, intrauterine growth retardation, prematurity, behavioral abnormalities, and perinatal mortality.