Selected Alu methylation levels in the gastric carcinogenesis cascade.

IF 2.3 3区生物学 Q2 MULTIDISCIPLINARY SCIENCES

PeerJ Pub Date : 2025-05-20 eCollection Date: 2025-01-01 DOI:10.7717/peerj.19485

Jiraroch Meevassana, Chawisa Wanda Vongsuly, Tanchanok Nakbua, Supitcha Kamolratanakul, Pichaya Thitiwanichpiwong, Fardeela Bin-Alee, Somboon Keelawat, Nakarin Kitkumthorn

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引用次数: 0

Abstract

Background: Genome-wide hypomethylation, a common epigenetic change that occurs during cancer development, primarily affects repetitive elements, such as Alu repeats. Consequently, Alu repeats can be used as a surrogate marker of genomic hypomethylation.

Methods: In this study, we aimed to investigate the correlation between Alu methylation levels and the multistage course of gastric carcinogenesis.

Results: We found that the Alu methylation levels in gastric cancer tissue decreased compared with those in normal gastric tissue, with the change in methylation levels and pattern being most significant between chronic gastritis and intestinal metaplasia. Moreover, Alu methylation levels were not associated with Helicobacter pylori or Epstein-Barr virus infection.

Conclusions: Finally, our sensitivity and specificity analyses suggested that Alu methylation level can be used to distinguish gastric cancer tissue from normal tissue. Thus, Alu methylation level shows promise as biomarker for gastric cancer diagnosis.

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选定的Alu甲基化水平在胃癌级联发生。

背景：全基因组低甲基化是一种发生在癌症发展过程中的常见表观遗传变化，主要影响重复元件，如Alu重复序列。因此，Alu重复序列可以作为基因组低甲基化的替代标记。方法：本研究旨在探讨Alu甲基化水平与胃癌多阶段发生的关系。结果：我们发现胃癌组织中Alu甲基化水平较正常胃组织降低，其中慢性胃炎和肠化生期间甲基化水平和模式的变化最为显著。此外，Alu甲基化水平与幽门螺杆菌或爱泼斯坦-巴尔病毒感染无关。结论：最后，我们的敏感性和特异性分析表明，Alu甲基化水平可以用来区分胃癌组织和正常组织。因此，Alu甲基化水平有望作为胃癌诊断的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

PeerJ MULTIDISCIPLINARY SCIENCES-

CiteScore

4.70

自引率

3.70%

发文量

1665

审稿时长

10 weeks

期刊介绍： PeerJ is an open access peer-reviewed scientific journal covering research in the biological and medical sciences. At PeerJ, authors take out a lifetime publication plan (for as little as $99) which allows them to publish articles in the journal for free, forever. PeerJ has 5 Nobel Prize Winners on the Board; they have won several industry and media awards; and they are widely recognized as being one of the most interesting recent developments in academic publishing.