Lobodontia-Affected Teeth Exhibit Compromised Integrity and Enamel Defects: A Deep Phenotyping Study.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2025-05-25 DOI:10.1111/odi.15390

Thanakorn Theerapanon, Narin Intarak, Sasiprapa Prommanee, Sunisa Somkana, Sirinya Kulvitit, Anucharte Srijunbarl, Junji Tagami, Thantrira Porntaveetus

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引用次数: 0

Abstract

Objective: Lobodontia, a complex tooth disorder characterized by carnivore-like dentition, presents unique clinical challenges. This study aimed to characterize the physical, mechanical, and ultrastructural properties of lobodontia teeth to inform precision treatment strategies.

Methods: This study included two extracted teeth (one from each lobodontia patient) and ten control teeth from healthy individuals. Clinical, radiographic, dental impression, and microstructural analyses were performed, including colorimetry, surface roughness, microCT, SEM, EDX, nanoindentation, and histology.

Results: Lobodontia teeth exhibited a distinctive multitubercular occlusal morphology, with deep grooves and multiple cusps. Radiographs showed dens invaginatus and taurodontism. Compared to controls, lobodontia teeth had increased surface roughness and color deviations. Although mineral composition was similar, lobodontia teeth showed significantly reduced hardness, elastic modulus, enamel thickness, and a disrupted dentinoenamel junction with a pronounced gap between enamel and dentin.

Conclusions: Lobodontia teeth exhibit compromised structural integrity, including diminished hardness, elasticity, and enamel thickness, alongside a defective dentinoenamel junction. These characteristics increase the risk of biofilm retention, infection, and malocclusion, necessitating personalized care approaches.

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脑白斑影响的牙齿表现出完整性受损和牙釉质缺陷：一项深入的表型研究。

目的：脑白质症是一种复杂的牙齿疾病，其特征是类似食肉动物的牙列，具有独特的临床挑战。本研究旨在描述白质牙的物理、机械和超微结构特性，为精确治疗策略提供信息。方法：本研究包括两颗拔牙（每颗患者一颗）和10颗健康对照牙。进行了临床、放射学、牙印和显微结构分析，包括比色法、表面粗糙度、微ct、扫描电镜、EDX、纳米压痕和组织学。结果：白牙具有明显的多结核状咬合形态，牙槽深，牙尖多。x线片显示牙槽、内凹和牛牙畸形。与对照组相比，白斑牙的表面粗糙度和颜色偏差增加。虽然矿物成分相似，但白斑牙的硬度、弹性模量、牙釉质厚度明显降低，牙本质与牙釉质之间的间隙明显，牙本质与牙釉质之间的连接被破坏。结论：Lobodontia牙齿表现出结构完整性受损，包括硬度、弹性和牙釉质厚度降低，以及牙本质与牙釉质交界处缺陷。这些特点增加了生物膜滞留、感染和错牙合的风险，需要个性化的护理方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.