Xin Ouyang, Senhua Chen, Qiling Chen, Heng Guo, Lan Liu, Hongju Liu, Chong Yan
{"title":"Anti-inflammatory polyketides from <i>Santalum album</i> derived endophytic fungus <i>Hypomontagnella</i> sp. TX-09.","authors":"Xin Ouyang, Senhua Chen, Qiling Chen, Heng Guo, Lan Liu, Hongju Liu, Chong Yan","doi":"10.1080/21501203.2024.2397600","DOIUrl":null,"url":null,"abstract":"<p><p>Four new lactones, including hypomonacid A (<b>1</b>) and hypomonone A-C (<b>4-6</b>), as well as nine known polyketide analogues (<b>2-3</b> and <b>7-13</b>) were obtained from endophytic fungus <i>Hypomontagnella</i> sp. TX-09 derived from <i>Santalum album</i>. Their planar structures were extensively established by analysing HRESIMS and NMR spectroscopic data. Stereochemistry of new compounds was determined by X-ray diffraction analysis and modified Mosher's method in combination with quantum-chemical ECD calculation. In addition, compounds <b>1</b> and <b>2</b> showed anti-inflammatory activity by inhibition of lipopolysaccharide (LPS)-induced NO production in RAW264.7 cells at 50 μmol/L without cytotoxicity. Among them, compound <b>1</b> inhibited the production of LPS-stimulated inflammation in mouse macrophage RAW264.7 cells by suppressing the expression of iNOS, TNF-α, IL-1β, and IL-6.</p>","PeriodicalId":18833,"journal":{"name":"Mycology","volume":"16 2","pages":"918-928"},"PeriodicalIF":4.4000,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096673/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mycology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/21501203.2024.2397600","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"MYCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Four new lactones, including hypomonacid A (1) and hypomonone A-C (4-6), as well as nine known polyketide analogues (2-3 and 7-13) were obtained from endophytic fungus Hypomontagnella sp. TX-09 derived from Santalum album. Their planar structures were extensively established by analysing HRESIMS and NMR spectroscopic data. Stereochemistry of new compounds was determined by X-ray diffraction analysis and modified Mosher's method in combination with quantum-chemical ECD calculation. In addition, compounds 1 and 2 showed anti-inflammatory activity by inhibition of lipopolysaccharide (LPS)-induced NO production in RAW264.7 cells at 50 μmol/L without cytotoxicity. Among them, compound 1 inhibited the production of LPS-stimulated inflammation in mouse macrophage RAW264.7 cells by suppressing the expression of iNOS, TNF-α, IL-1β, and IL-6.
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