Research progress in the regulatory mechanism of silent information regulator 1 in sepsis (Review).

Abstract

Sepsis is characterized by a dysregulated systemic inflammatory response to infection. Despite substantial advances in its treatment, sepsis remains a significant global health burden. An understanding of the underlying mechanisms driving sepsis is crucial for the development of targeted therapeutic strategies. Silent information regulator 1 (SIRT1), a member of the class III histone deacetylases, plays a pivotal role in regulating gene expression by catalyzing the deacetylation of lysine residues on non‑histone and histone proteins. SIRT1 has been shown to exert significant anti‑inflammatory, anti‑oxidative, anti‑apoptotic and metabolic regulatory effects, making it a potential therapeutic target for sepsis. The present study reviewed the latest research progress on the signaling pathways modulated by SIRT1 in sepsis and its associated regulatory mechanisms to further elucidate the pathogenesis of sepsis and guide its clinical treatment.