[Chronic HBV infection affects health-related quality of life in pregnant women in the second and third trimesters and postpartum period: a prospective cohort study].

Q3 Medicine
Yueying Deng, Yawen Geng, Tingting Peng, Junchao Qiu, Lijuan He, Dan Xie, Ziren Chen, Shi Ouyang, Shengguang Yan
{"title":"[Chronic HBV infection affects health-related quality of life in pregnant women in the second and third trimesters and postpartum period: a prospective cohort study].","authors":"Yueying Deng, Yawen Geng, Tingting Peng, Junchao Qiu, Lijuan He, Dan Xie, Ziren Chen, Shi Ouyang, Shengguang Yan","doi":"10.12122/j.issn.1673-4254.2025.05.12","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the impact of HBV infection on pre- and postpartum health-related quality of life (HRQoL) in pregnant women.</p><p><strong>Methods: </strong>A prospective matched cohort consisting of 70 HBV-infected and 70 healthy pregnant women was recruited from the Fifth Affiliated Hospital of Guangzhou Medical University between April 17 and September 25, 2023. HRQoL of the participants was assessed at 16-24 weeks of gestation, between 32 weeks and delivery, and 5-13 weeks postpartum. Mixed linear models were used for evaluating temporal trends of HRQoL changes, and univariate ANOVA with multiple linear regression was used to identify the predictors of HRQoL.</p><p><strong>Results: </strong>Compared with healthy pregnant women, HBV-infected pregnant women had consistently lower total HRQoL scores across all the 3 intervals, with the lowest scores observed between 32 weeks of gestation and delivery, during which these women had significantly reduced mental component scores (74.27±13.43 <i>vs</i> 80.21±12.9, <i>P</i>=0.009) and postpartum mental (76.52±16.19 <i>vs</i> 85.02±6.51, <i>P</i><0.001) and physical component scale scores (77.17±14.71 <i>vs</i> 83.09±10.1, <i>P</i>=0.009). HBV infection was identified as an independent risk factor affecting HRQoL during late pregnancy and postpartum periods. Additional independent risk factors for postpartum HRQoL reduction included self-pay medical expenses, spouse's neutral attitude toward the current pregnancy, and preexisting comorbidities (all <i>P</i><0.05).</p><p><strong>Conclusions: </strong>HRQoL of pregnant women deteriorates progressively in late pregnancy, and HBV infection exacerbates reductions of physical function and role emotion in late pregnancy and after delivery, suggesting the importance of targeted interventions for financial burdens, partner support and comorbid conditions to improve HRQoL of pregnant women with HBV infection.</p>","PeriodicalId":18962,"journal":{"name":"南方医科大学学报杂志","volume":"45 5","pages":"995-1002"},"PeriodicalIF":0.0000,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104740/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"南方医科大学学报杂志","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.12122/j.issn.1673-4254.2025.05.12","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

Abstract

Objectives: To evaluate the impact of HBV infection on pre- and postpartum health-related quality of life (HRQoL) in pregnant women.

Methods: A prospective matched cohort consisting of 70 HBV-infected and 70 healthy pregnant women was recruited from the Fifth Affiliated Hospital of Guangzhou Medical University between April 17 and September 25, 2023. HRQoL of the participants was assessed at 16-24 weeks of gestation, between 32 weeks and delivery, and 5-13 weeks postpartum. Mixed linear models were used for evaluating temporal trends of HRQoL changes, and univariate ANOVA with multiple linear regression was used to identify the predictors of HRQoL.

Results: Compared with healthy pregnant women, HBV-infected pregnant women had consistently lower total HRQoL scores across all the 3 intervals, with the lowest scores observed between 32 weeks of gestation and delivery, during which these women had significantly reduced mental component scores (74.27±13.43 vs 80.21±12.9, P=0.009) and postpartum mental (76.52±16.19 vs 85.02±6.51, P<0.001) and physical component scale scores (77.17±14.71 vs 83.09±10.1, P=0.009). HBV infection was identified as an independent risk factor affecting HRQoL during late pregnancy and postpartum periods. Additional independent risk factors for postpartum HRQoL reduction included self-pay medical expenses, spouse's neutral attitude toward the current pregnancy, and preexisting comorbidities (all P<0.05).

Conclusions: HRQoL of pregnant women deteriorates progressively in late pregnancy, and HBV infection exacerbates reductions of physical function and role emotion in late pregnancy and after delivery, suggesting the importance of targeted interventions for financial burdens, partner support and comorbid conditions to improve HRQoL of pregnant women with HBV infection.

[慢性HBV感染影响妊娠中期和晚期及产后孕妇健康相关生活质量:一项前瞻性队列研究]。
目的:评价HBV感染对孕妇产前和产后健康相关生活质量(HRQoL)的影响。方法:于2023年4月17日至9月25日在广州医科大学第五附属医院招募70名hbv感染孕妇和70名健康孕妇作为前瞻性匹配队列。参与者的HRQoL在妊娠16-24周、分娩32周和产后5-13周进行评估。采用混合线性模型评价HRQoL变化的时间趋势,采用单因素方差分析结合多元线性回归确定HRQoL的预测因子。结果:与健康孕妇相比,hbv感染孕妇的HRQoL总分在所有3个时间段均持续降低,最低评分出现在妊娠32周至分娩期间,心理成分评分(74.27±13.43比80.21±12.9,P=0.009)和产后精神成分评分(76.52±16.19比85.02±6.51,P比83.09±10.1,P=0.009)均显著降低。HBV感染是影响妊娠后期和产后HRQoL的独立危险因素。产后HRQoL降低的其他独立危险因素包括自费医疗费用、配偶对当前妊娠的中立态度和既往合并症(均为p)。孕妇HRQoL在妊娠后期逐渐恶化,HBV感染加剧了妊娠后期和分娩后身体功能和角色情绪的下降,提示针对经济负担、伴侣支持和合并症进行针对性干预对改善HBV感染孕妇HRQoL的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
南方医科大学学报杂志
南方医科大学学报杂志 Medicine-Medicine (all)
CiteScore
1.50
自引率
0.00%
发文量
208
期刊介绍:
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信