{"title":"Role of amino acid metabolism in osteoporosis: Effects on the bone microenvironment and treatment strategies (Review).","authors":"Chang Zhou, Jiaheng Zhang, Qizhi Liu, Yanghongxu Guo, Mengyuan Li, Jing Tao, Sujuan Peng, Ronghui Li, Xianguang Deng, Guomin Zhang, Huiping Liu","doi":"10.3892/mmr.2025.13577","DOIUrl":null,"url":null,"abstract":"<p><p>Osteoporosis is a metabolic disease characterized by an imbalance in bone remodeling. Its pathogenesis involves a functional imbalance of osteoblasts, osteoclasts and bone marrow mesenchymal stem cells. Amino acid metabolism is a key biochemical process for maintaining biological activities, including protein synthesis, energy supply and signal transduction. Amino acid metabolism affects bone homeostasis by regulating osteocyte function and the bone microenvironment. Branched‑chain amino acid and aromatic amino acid metabolism are involved in the regulation of bone mineral density. The present review demonstrates the mechanism of amino acid metabolism in osteoporosis and its potential therapeutic value. In addition, the present review aimed to summarize the application of Mendelian randomization and metabolomic methods to provide a reference for future research and clinical interventions.</p>","PeriodicalId":18818,"journal":{"name":"Molecular medicine reports","volume":"32 2","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular medicine reports","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3892/mmr.2025.13577","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/26 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
Osteoporosis is a metabolic disease characterized by an imbalance in bone remodeling. Its pathogenesis involves a functional imbalance of osteoblasts, osteoclasts and bone marrow mesenchymal stem cells. Amino acid metabolism is a key biochemical process for maintaining biological activities, including protein synthesis, energy supply and signal transduction. Amino acid metabolism affects bone homeostasis by regulating osteocyte function and the bone microenvironment. Branched‑chain amino acid and aromatic amino acid metabolism are involved in the regulation of bone mineral density. The present review demonstrates the mechanism of amino acid metabolism in osteoporosis and its potential therapeutic value. In addition, the present review aimed to summarize the application of Mendelian randomization and metabolomic methods to provide a reference for future research and clinical interventions.
期刊介绍：
Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.
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