Mon4 as a novel monocyte subset with distinct profile and predictor of poor outcomes in individuals with myocardial infarction.

IF 2.3 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Maxime Boidin, Gregory Y H Lip, Eduard Shantsila
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引用次数: 0

Abstract

Recently, a new monocyte subset known as Mon4, characterized by distinct gene expressions, has been identified but remains poorly characterized. In this study, our objective was to comprehensively characterise Mon4 in healthy individuals and explore its correlation with major adverse cardiovascular events (MACE) in patients with ST-elevation myocardial infarction (STEMI). Our study enrolled 20 healthy individuals and 245 STEMI patients who underwent primary percutaneous coronary intervention (PCI). We analysed monocyte subsets using flow cytometry and collected bone marrow samples from 11 healthy individuals. Cardiac function assessments were performed in STEMI patients through echocardiography within 3 days post-PCI. Mon4 displayed significant differences compared to Mon1, Mon2, and Mon3 in various parameters among healthy individuals, underscoring its distinct profile. In STEMI patients, above-median Mon4 counts were associated with a increased risk of MACE (hazard ratio [HR] 3.11, 95% confidence interval [CI] 1.55-6.24, p = 0.01) and heart failure (HR 3.25, 95% CI 1.14-9.24, p = 0.03) after adjusting for other predictive factors. This study highlights the unique characteristics of Mon4 and its clinical significance. The distinctive gene signature of Mon4, coupled with its association with MACE and heart failure, suggests its potential utility as a biomarker for risk assessment in MI patients. Further investigations are warranted to explore the therapeutic potential of targeting Mon4 in reducing cardiovascular complications following MACE.

Mon4作为一种新的单核细胞亚群,在心肌梗死患者中具有独特的特征和不良预后的预测因子。
最近,一种新的单核细胞亚群被称为Mon4,其特征是不同的基因表达,已经被确定,但仍然缺乏特征。在这项研究中,我们的目的是全面表征健康个体的Mon4,并探讨其与st段抬高型心肌梗死(STEMI)患者主要不良心血管事件(MACE)的相关性。我们的研究招募了20名健康个体和245名接受了初级经皮冠状动脉介入治疗(PCI)的STEMI患者。我们使用流式细胞术分析单核细胞亚群,并收集了11名健康个体的骨髓样本。STEMI患者在pci术后3天内通过超声心动图进行心功能评估。在健康个体中,Mon4与Mon1、Mon2和Mon3在各种参数上表现出显著差异,强调了其独特的特征。在STEMI患者中,高于中位数的Mon4计数与MACE(危险比[HR] 3.11, 95%可信区间[CI] 1.55-6.24, p = 0.01)和心力衰竭(HR 3.25, 95% CI 1.14-9.24, p = 0.03)的风险增加相关。本研究突出了Mon4的独特特点及其临床意义。Mon4独特的基因特征,加上它与MACE和心力衰竭的关联,表明它作为心肌梗死患者风险评估的生物标志物的潜在效用。需要进一步的研究来探索靶向Mon4在减少MACE后心血管并发症方面的治疗潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
9.20
自引率
0.00%
发文量
112
审稿时长
4-8 weeks
期刊介绍: The Journal of Thrombosis and Thrombolysis is a long-awaited resource for contemporary cardiologists, hematologists, vascular medicine specialists and clinician-scientists actively involved in treatment decisions and clinical investigation of thrombotic disorders involving the cardiovascular and cerebrovascular systems. The principal focus of the Journal centers on the pathobiology of thrombosis and vascular disorders and the use of anticoagulants, platelet antagonists, cell-based therapies and interventions in scientific investigation, clinical-translational research and patient care. The Journal will publish original work which emphasizes the interface between fundamental scientific principles and clinical investigation, stimulating an interdisciplinary and scholarly dialogue in thrombosis and vascular science. Published works will also define platforms for translational research, drug development, clinical trials and patient-directed applications. The Journal of Thrombosis and Thrombolysis'' integrated format will expand the reader''s knowledge base and provide important insights for both the investigation and direct clinical application of the most rapidly growing fields in medicine-thrombosis and vascular science.
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