Integrating natural products with modern medicine in the treatment of gouty arthritis: a review.

IF 4.6 2区医学 Q2 IMMUNOLOGY

Inflammopharmacology Pub Date : 2025-05-26 DOI:10.1007/s10787-025-01784-0

Sherif S Abdel Mageed, Fatma Abdelhakim Mohamed, Marina Sobhy, Ahmed H Elosaily, Ahmed M El-Dessouki, Heba R Ghaiad, Mai A Abd-Elmawla, Mohamed I Fahmy, Mennat-Allah M Hassan, Riham A El-Shiekh, Nourhan M Abdelmaksoud

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Abstract

Gout is an inflammatory form of arthritis caused by hyperuricemia, a condition in which uric acid levels in the body become excessively high. When this occurs, monosodium urate (MSU) crystals can accumulate in the joints, triggering intense pain, swelling, and inflammation. If left untreated, gout can lead to joint damage and other complications. Diet is a key factor in the development and management of gout since some meals may increase uric acid levels while others can help relieve symptoms. To reduce circulating urate levels, commonly used drugs include allopurinol and febuxostat. However, the intake of these medications is associated with undesirable side effects. As a result, the development of a novel active, safe anti-hyperuricaemic and anti-inflammatory medicine could be extremely beneficial in gout treatment. Natural products have become a source of new medications because of their high efficacy and low side effects, which are based on the presence of complex bioactive components. A rising number of researchers document that traditional medications can reduce serum urate levels. This article is intended to trace which herbal remedies could alleviate hyperuricemia, as well as their mechanism of actions.

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结合天然产物与现代医学治疗痛风性关节炎：综述。

痛风是由高尿酸血症引起的关节炎的一种炎症形式，在这种情况下，体内的尿酸水平变得过高。当这种情况发生时，尿酸钠（MSU）晶体会积聚在关节中，引发剧烈疼痛、肿胀和炎症。如果不及时治疗，痛风会导致关节损伤和其他并发症。饮食是发展和控制痛风的关键因素，因为一些食物可能会增加尿酸水平，而另一些食物可以帮助缓解症状。为了降低循环尿酸水平，常用的药物包括别嘌呤醇和非布司他。然而，这些药物的摄入与不良的副作用有关。因此，开发一种新型的、有效的、安全的抗高尿酸血症和抗炎药物可能对痛风治疗非常有益。天然产物由于其基于复杂生物活性成分的高效、低副作用而成为新药的来源。越来越多的研究人员证明，传统药物可以降低血清尿酸水平。本文旨在探讨哪些中药可以减轻高尿酸血症，以及它们的作用机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Inflammopharmacology IMMUNOLOGYTOXICOLOGY-TOXICOLOGY

CiteScore

8.00

自引率

3.40%

发文量

200

期刊介绍： Inflammopharmacology is the official publication of the Gastrointestinal Section of the International Union of Basic and Clinical Pharmacology (IUPHAR) and the Hungarian Experimental and Clinical Pharmacology Society (HECPS). Inflammopharmacology publishes papers on all aspects of inflammation and its pharmacological control emphasizing comparisons of (a) different inflammatory states, and (b) the actions, therapeutic efficacy and safety of drugs employed in the treatment of inflammatory conditions. The comparative aspects of the types of inflammatory conditions include gastrointestinal disease (e.g. ulcerative colitis, Crohn''s disease), parasitic diseases, toxicological manifestations of the effects of drugs and environmental agents, arthritic conditions, and inflammatory effects of injury or aging on skeletal muscle. The journal has seven main interest areas: -Drug-Disease Interactions - Conditional Pharmacology - i.e. where the condition (disease or stress state) influences the therapeutic response and side (adverse) effects from anti-inflammatory drugs. Mechanisms of drug-disease and drug disease interactions and the role of different stress states -Rheumatology - particular emphasis on methods of measurement of clinical response effects of new agents, adverse effects from anti-rheumatic drugs -Gastroenterology - with particular emphasis on animal and human models, mechanisms of mucosal inflammation and ulceration and effects of novel and established anti-ulcer, anti-inflammatory agents, or antiparasitic agents -Neuro-Inflammation and Pain - model systems, pharmacology of new analgesic agents and mechanisms of neuro-inflammation and pain -Novel drugs, natural products and nutraceuticals - and their effects on inflammatory processes, especially where there are indications of novel modes action compared with conventional drugs e.g. NSAIDs -Muscle-immune interactions during inflammation [...]