Choroid plexus enlargement correlates with subcortical tau deposition in progressive supranuclear palsy.

IF 5.9 1区 医学 Q1 NEUROSCIENCES
Na Wang, JiaYing Lu, XueLing Liu, JianPeng Liu, YuCheng Lu, ChengLing Xu, SiRong Piao, LiQin Yang, FengTao Liu, YuXin Li
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引用次数: 0

Abstract

Objective: The choroid plexus (CP) has gained renewed attention for its role in waste clearance in neurodegenerative disorders. However, its involvement in progressive supranuclear palsy (PSP) remains unclear. This study aimed to investigate CP volume changes in patients with PSP compared to Parkinson's disease (PD), and explore its relationship with tau deposition in PSP patients.

Methods: A total of 204 participants (92 PSP, 78 PD, 34 healthy controls (HC)) underwent structural MRI, with 63 PSP patients receiving 18F-Florzolotau positron emission tomography. CP volume was compared across the three groups, and its ability to differentiate PSP from PD was assessed. Mean standardized uptake value ratios (SUVRs) from bilateral subcortical regions were extracted: ROIs1 including early involved nuclei of red nucleus, subthalamic nucleus, raphe nuclei, and globus pallidus; ROIs2 including late involved nuclei of substantia nigra, locus coeruleus, putamen, and thalamus. The relationship between CP volume, tau deposition and clinical assessments was analyzed.

Results: PSP patients exhibited increased CP volume compared to PD and HC groups. The area under the curve value was 0.84 in differentiating PSP from PD, with CP volume and age as predictive variables. In the PSP group, CP volume was positively correlated with mean 18F-Florzolotau SUVRs in the ROIs2. Furthermore, in the PSP and PD groups, CP volume was negatively correlated with cognitive scores, but positively correlated with motor scores.

Conclusions: CP enlargement is a distinguishing feature of PSP and may serve as an imaging biomarker for tau accumulation, offering potential for differentiating PSP from PD.

在进行性核上性麻痹中,脉络膜丛扩大与皮层下tau沉积相关。
目的:脉络膜丛(CP)因其在神经退行性疾病中废物清除中的作用而重新受到关注。然而,其与进行性核上性麻痹(PSP)的关系尚不清楚。本研究旨在探讨PSP患者与帕金森病(PD)相比CP体积的变化,并探讨其与PSP患者tau沉积的关系。方法:共204例患者(PSP 92例,PD 78例,健康对照34例)行结构MRI检查,其中63例PSP患者行18F-Florzolotau正电子发射断层扫描。比较三组的CP体积,并评估其区分PSP和PD的能力。提取双侧皮质下区域的平均标准化摄取值比(SUVRs): ROIs1包括早期受累的红核、丘脑下核、中音核和苍白球核;ROIs2包括晚期累及的黑质核、蓝斑核、壳核和丘脑。分析脑膜体积、tau沉积与临床评价的关系。结果:与PD组和HC组相比,PSP患者CP体积增加。区分PSP与PD的曲线下面积为0.84,CP体积和年龄为预测变量。在PSP组中,CP体积与rois中平均18F-Florzolotau suv呈正相关。此外,在PSP和PD组中,CP体积与认知评分呈负相关,而与运动评分呈正相关。结论:CP增大是PSP的显著特征,可能作为tau积累的成像生物标志物,为区分PSP和PD提供了可能。
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来源期刊
Fluids and Barriers of the CNS
Fluids and Barriers of the CNS Neuroscience-Developmental Neuroscience
CiteScore
10.70
自引率
8.20%
发文量
94
审稿时长
14 weeks
期刊介绍: "Fluids and Barriers of the CNS" is a scholarly open access journal that specializes in the intricate world of the central nervous system's fluids and barriers, which are pivotal for the health and well-being of the human body. This journal is a peer-reviewed platform that welcomes research manuscripts exploring the full spectrum of CNS fluids and barriers, with a particular focus on their roles in both health and disease. At the heart of this journal's interest is the cerebrospinal fluid (CSF), a vital fluid that circulates within the brain and spinal cord, playing a multifaceted role in the normal functioning of the brain and in various neurological conditions. The journal delves into the composition, circulation, and absorption of CSF, as well as its relationship with the parenchymal interstitial fluid and the neurovascular unit at the blood-brain barrier (BBB).
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